A linear population risk model used by the U.S. Food and Drug Administration (FDA) Center for Veterinary Medicine (CVM) estimates the risk of human cases of campylobacteriosis caused by fluoroquinolone-resistant Campylobacter. Among the cases of campylobacteriosis attributed to domestically produced chicken, the fluoroquinolone resistance is assumed to result from the use of fluoroquinolones in poultry in the United States. Properties of the linear population risk model are contrasted with those of a farm-to-fork model commonly used for microbial risk assessments. The utility of the linear population model for the purpose for which it was used by CVM is discussed.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.0272-4332.2005.00570.xDOI Listing

Publication Analysis

Top Keywords

linear population
12
population risk
8
risk model
8
cases campylobacteriosis
8
risk
5
linear
4
linear model
4
model managing
4
managing risk
4
risk antimicrobial
4

Similar Publications

Distribution of opioid analgesics by community racial/ethnic and socioeconomic profiles, 2011-2021.

Pain

January 2025

Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.

Rapid declines in opioid analgesics dispensed in American communities since 2011 raise concerns about inadequate access to effective pain management among patients for whom opioid therapies are appropriate, especially for those living in racial/ethnic minority and socioeconomically deprived communities. Using 2011 to 2021 national data from the Automated Reports and Consolidated Ordering System and generalized linear models, this study examined quarterly per capita distribution of oxycodone, hydrocodone, and morphine (in oral morphine milligram equivalents [MMEs]) by communities' racial/ethnic and socioeconomic profiles. Communities (defined by 3-digit-zip codes areas) were classified as "majority White" (≥50% self-reported non-Hispanic White population) vs "majority non-White.

View Article and Find Full Text PDF

Background: Similar to T1 colon cancer (CC), risk stratification may guide T2 CC treatment and reduce unnecessary major surgery. In this study, prediction models were developed that could identify T2 CC patients with a lower risk of lymph node metastasis (LNM) for whom (intensive) follow-up after local treatment could be considered.

Methods: A nationwide cohort study was performed involving pT2 CC patients who underwent surgery between 2012 and 2020, using data from the Dutch ColoRectal Audit, which were linked to the Nationwide Pathology Databank.

View Article and Find Full Text PDF

Purpose: Elevated methylglyoxal (MGO) levels and altered immune cell responses are observed in diabetes. MGO is thought to modulate immune cell activation. The current study investigated whether fasting or post-glucose-load plasma MGO concentrations are associated with circulating immune cell counts and activation in a large cohort study.

View Article and Find Full Text PDF

Investigating the effects of urbanization at the county level on the balance of the carbon budget is essential for progress toward achieving "dual carbon" objectives at the county scale. Based on land use and economic data, this study elucidates the spatiotemporal evolution of urbanization and carbon budget balance ratio in 84 counties in Jiangxi Province from 1980 to 2020. Optimal geographic detectors and geographically weighted random forests were used to explore the impact of urbanization on the carbon budget balance ratio.

View Article and Find Full Text PDF

Background: Chronic stress, characterized by sustained activation of physiological stress response systems, is a key risk factor for numerous health conditions. Allostatic load (AL), a biomarker of cumulative physiological stress, offers a quantitative measure of this burden. Lifestyle habits such as alcohol consumption and smoking, alongside environmental exposures to toxic metals like lead, cadmium, and mercury, were individually implicated in increasing AL.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!