[Tyramine and serotonin syndromes. Pharmacological, medical and legal remarks].

Vertex

Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Published: July 2005

The tyramine syndrome and the serotonin syndrome are a complex of signs and symptoms that are thought to be largely attributable to drug - drug interactions or drug - food interactions that enhances norepinephrine o serotonin activity. This article reviews: pharmacological basis of those syndromes; clinical features; forbidden foods, drug-drug interactions, and treatment options. Finally a set of legal recommendations are proposed to avoid liability litigations.

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