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Flow-Dependent Modulation of Endothelial Ca Dynamics by Small Conductance Ca-Activated K Channels in Mouse Carotid Arteries.
Biomedicines
December 2024
Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
Background: Small conductance Ca activated K channels (K2.3) are important regulators of vascular function. They provide Ca-dependent hyperpolarization of the endothelial membrane potential, promoting agonist-induced vasodilation.
View Article and Find Full Text PDFThe Acute Ingestion of Yerba Mate (Ilex paraguariensis) Infusion Does Not Modify Endothelial Function, Hemodynamics, or Heart Rate Variability: A Randomized Crossover Clinical Trial.
Plant Foods Hum Nutr
December 2024
Department of Physiological Sciences, Biological Sciences Center, Federal University of Santa Catarina - Rua da Prefeitura Universitária, Córrego Grande, Florianópolis, SC, 88037-000, Brazil.
Background And Aims: Herbal plants may contribute to reducing the incidence of cardiovascular disease. Yerba mate (YM) emerges as a candidate to improve endothelial function, hemodynamics, and heart rate variability (HRV) due to its antioxidant and anti-inflammatory properties, potentially decreasing cardiovascular risk. Therefore, studies are needed to assess the effect of YM ingestion on these parameters.
View Article and Find Full Text PDFDanggui Liuhuang Decoction ameliorates endothelial dysfunction by inhibiting the JAK2/STAT3 mediated inflammation.
J Ethnopharmacol
January 2025
Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200333, China. Electronic address:
Ethnopharmacological Relevance: Vascular endothelial dysfunction (VED) is recognized as a key triggering diabetic vascular complications. Danggui Liuhuang Decoction (DGLHD) has shown potential in mitigating these complications. However, the clinical efficacy of DGLHD in enhancing endothelial function, as well as the molecular mechanisms underlying its alleviation of Type 2 Diabetes-Related Vascular Endothelial Dysfunction (T2DM-VED), remains insufficiently understood.
View Article and Find Full Text PDFMung Bean Functional Protein Enhances Endothelial Function via Antioxidant Activity and Inflammation Modulation in Middle-Aged Adults: A Randomized Double-Blind Trial.
Foods
October 2024
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
This study examines the impact of mung bean () protein consumption on endothelial function in middle-aged adults, focusing on antioxidant enzyme activity and anti-inflammatory markers. Mung beans have shown promise in enhancing cardiovascular function, lowering blood pressure, and improving lipid profiles, but the underlying mechanisms of these functions remain unclear. Conducted as a three-arm randomized, double-blind, placebo-controlled trial, this study involved male and female participants aged 45 to 60 and assigned them to consume either a placebo or a mung bean functional drink containing 10 or 15 g of mung bean protein daily for six weeks.
View Article and Find Full Text PDFEndothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids.
Sci Adv
September 2024
School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
How cardiovascular activity interacts with lipid homeostasis is incompletely understood. We postulated a role for blood flow acting at endothelium in lipid regulatory organs. Transcriptome analysis was performed on livers from mice engineered for deletion of the flow-sensing PIEZO1 channel in endothelium.
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