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Interventions for BK virus infection in kidney transplant recipients.
Cochrane Database Syst Rev
October 2024
Department of Renal Medicine, The Canberra Hospital, Canberra, Australia.
Article Synopsis
- BK virus-associated nephropathy (BKVAN) is a complication in kidney transplantation due to BK virus infection, requiring careful screening and management primarily through reduced immunosuppression, as no effective antiviral therapy exists.
- This review evaluated the effectiveness and risks of various interventions for treating or preventing BKVAN among kidney transplant recipients, including examining randomized controlled trials and cohort studies.
- The review included 12 RCTs with a total of 2,669 participants, analyzing data through rigorous methods to assess the quality and effectiveness of these interventions.
Aim: BK polyomavirus infection is a challenging complication of renal transplantation. The management is not standardized and is based on reports from transplantation centers' experiences, usually with small sample sizes. Therefore, we aimed to present our countrywide experience with BK virus nephropathy (BKVN) in renal transplant recipients.
View Article and Find Full Text PDFThe Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation.
Transplantation
September 2024
Division of Transplantation and Clinical Virology, Department of Biomedicine, Faculty of Medicine, University of Basel, Basel, Switzerland.
BK polyomavirus (BKPyV) remains a significant challenge after kidney transplantation. International experts reviewed current evidence and updated recommendations according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Risk factors for BKPyV-DNAemia and biopsy-proven BKPyV-nephropathy include recipient older age, male sex, donor BKPyV-viruria, BKPyV-seropositive donor/-seronegative recipient, tacrolimus, acute rejection, and higher steroid exposure.
View Article and Find Full Text PDFBK virus-associated hemorrhagic cystitis in pediatric stem cell transplantation: a case report and scoping review.
Front Pediatr
February 2024
Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
Introduction: BK virus-associated hemorrhagic cystitis (BK-HC) is a debilitating and poorly understood complication of hematopoietic stem cell transplantation (SCT). Hematuria, dysuria, and other symptoms associated with BK-HC are common in the immediate post-SCT period, making BK-HC difficult to distinguish from other conditions presenting with these symptoms. Despite published criteria for diagnosis, the degree to which these criteria are consistently applied to either clinical diagnosis or to studies informing BK-HC management is unclear.
View Article and Find Full Text PDFHigh-Dose Intravenous Immunoglobulin to Treat Anti-Thymocyte Globulin Induction-Related BK Virus and Cytomegalovirus Infection in Patients with ABO-Incompatible Kidney Transplantation.
Transplant Proc
April 2024
Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea. Electronic address:
Background: ABO-incompatible (ABOi) transplantation is a novel method transplantation method that carries a heightened risk of infection caused by the use of high immunosuppressant doses. This elevated risk is particularly concerning for viral infections, such as cytomegalovirus (CMV) and the BK virus (BKV) increases. Herein, we present a case where high-dose intravenous immunoglobulin (IVIG) was effective in treating viral infections after transplantation.
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