AI Article Synopsis
- The study investigates how suspended cells respond to step stress, highlighting a passive relaxation process due to a cross-linked actin structure beneath the membrane.
- The transition from fluid to solid state aligns with the unbinding times of cross-linking proteins, showing that elastic effects from entangled filaments are minimal.
- The symmetry of suspended cells leads to consistent viscoelastic properties, unlike adherent cells, influencing how different cell types respond to mechanical stimuli over time.
Article Abstract
A step stress deforming suspended cells causes a passive relaxation, due to a transiently cross-linked isotropic actin cortex underlying the cellular membrane. The fluid-to-solid transition occurs at a relaxation time coinciding with unbinding times of actin cross-linking proteins. Elastic contributions from slowly relaxing entangled filaments are negligible. The symmetric geometry of suspended cells ensures minimal statistical variability in their viscoelastic properties in contrast with adherent cells and thus is defining for different cell types. Mechanical stimuli on time scales of minutes trigger active structural responses.
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| http://dx.doi.org/10.1103/PhysRevLett.94.098103 | DOI Listing |
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