AI Article Synopsis
- * The research involved 39 patients with colorectal cancer, 18 with gastric cancer, and 22 healthy controls, measuring NO and FN levels through specific reactions.
- * Results showed elevated NO levels in cancer patients and reduced FN levels in colorectal cancer, suggesting these molecules may influence cancer development, potentially guiding future treatment strategies.
Article Abstract
Background/aims: Gastrointestinal cancers are one of the most common malignancies in the world. Various etiologic factors have been proposed including viruses, chemical agents, and genetic factors. The aim of this study was to investigate the role of fibronectin (FN) and nitric oxide (NO) in gastric and colorectal cancers.
Methodology: Thirty-nine patients (22 males, 17 females) with colorectal, 18 (10 males, 8 females) with gastric cancer, and 22 healthy control subjects were included in the study. The Griess reaction was used for the measurement of NO levels. An immunochemical reaction was used for measurement of FN levels.
Results: We found increased levels of NO in colon and gastric cancer, and decreased levels of FN in colon cancer when compared with healthy control subjects. Neither FN nor NO levels were associated with age, gender, stage of disease and survival status. No significant association was found between NO and FN levels.
Conclusions: In conclusion, these two molecules might contribute to the pathogenesis of gastrointestinal cancers. The combination with standard chemotherapy and nitric oxide synthase inhibitors may be useful for the treatment of gastrointestinal cancer.
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