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Purpura fulminans due to bacteraemia in an unsplectomised immunocompetent adult without primary hypocomplementaemia.
BMJ Case Rep
May 2022
Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, USA.
Article Synopsis
- Invasive pneumococcal disease primarily affects high-risk individuals, including those with asplenia and certain immune deficiencies, and can lead to severe complications like DIC and purpura fulminans, which have high mortality rates.
- A case study details an immunocompetent woman in her 50s with an intact spleen who developed septic shock and quickly progressed to multiorgan dysfunction and purpura fulminans.
- Despite receiving intensive treatment—including broad-spectrum antibiotics, factor replacement, and supportive therapies—she ultimately died from multiorgan failure.
Cryoglobulinaemia associated with hepatitis C virus: influence of HCV genotypes, HCV-RNA viraemia and HIV coinfection.
J Viral Hepat
October 2007
Department of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain.
To determine whether the clinical and immunological expression of patients with cryoglobulinaemia associated with chronic hepatitis C virus (HCV) infection varied according to HCV-RNA load, HCV genotype or human immunodeficiency virus (HIV) coinfection. We studied 340 HCV patients (188 women and 152 men, with a mean age of 49 years) consecutively diagnosed with cryoglobulinaemia between 1993 and 2003 in our hospital. HCV infection was confirmed by serum HCV-RNA determination in all patients.
View Article and Find Full Text PDFGlomerulonephritis after ventriculo-atrial shunt.
QJM
December 1995
Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
We describe five patients with glomerulonephritis (GN) associated with cerebrospinal fluid shunt insertion to relieve hydrocephalus. A ventriculo-atrial (V-A) shunt had been placed on average 12.5 years prior to the diagnosis of nephritis (range 0.
View Article and Find Full Text PDFSerum levels of complement components C3, C4 and factor B were measured in twenty-five patients with Staphylococcus aureus bacteraemia. The levels of C3 were depressed in nine patients, five of whom also had low C4 levels, indicating activation of complement via the classical pathway. Two patients with low C3 levels also had low factor B levels, one of these being in association with a low C4 level, which indicates activation of both the classical and alternative pathways, the latter being via the C3b feedback cycle.
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