Females of Drosophila melanogaster and males of D. simulans hybridizing in a nonchoice condition were artificially selected for 12 generations. The frequency of hybridization increased from 10% to 79%. Response to selection occurred in both species, particularly in D. melanogaster. Female receptivity was the primary sexual trait that accounted for breaking up sexual isolation in these species, but it remained unclear which elements of the D. simulans male courtship were involved.
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