A paper by Martinvalet et al. (2005) in this issue of Immunity examines the mechanisms used by granzyme A to kill target cells after its cytoplasmic injection by cytotoxic lymphocytes. They show that this protease induces mitochondrial damage and generation of reactive oxygen species that are necessary for cell death.
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| http://dx.doi.org/10.1016/j.immuni.2005.03.003 | DOI Listing |
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