AI Article Synopsis

  • The study aimed to explore the role of basic fibroblast growth factor (bFGF) and transforming growth factor beta-1 (TGF beta-1) in cardiac hypertrophy resulting from either volume or pressure overload in patients.
  • It involved 32 patients, divided into two groups based on the type of overload, and compared them to a control group of patients who died of non-cardiac diseases, using various techniques to analyze gene expression and heart tissue.
  • The findings indicated that levels of bFGF and TGF beta-1, along with changes in cardiomyocyte size and extracellular matrix composition, were significantly increased in patients experiencing either type of overload, highlighting their potential role in cardiac hypertrophy.

Article Abstract

Objectives: The aim of the study was to investigate the pathogenic role of intracardiac basic fibroblast growth factor (bFGF) and transforming growth factor beta-1 (TGF beta-1) mRNA and their protein expression level in patients with ventricular volume or pressure-overload.

Background: Myocardial hypertrophy is responsiveness of cardiomyocytes and interstitial cells to ventricular stress produced by ventricular preload or/and afterload and a series of growth factors. However, the molecular mechanism by which the changes of bFGF and TGF beta-1 mRNA and their protein expression level in patients with volume or pressure-overload lead to distinct forms of cardiac hypertrophy is unclear.

Methods: 32 patients were divided into two groups: 16 patients with cardiac volume overload leading to left ventricular hypertrophy (VG) and 16 patients with pressure overload leading to right ventricular hypertrophy (PG), respectively, as compared with 5 unexpected deaths of noncardiac disease (CG), which is determinated by echocardiography and/or pathologic examination following operation; intracardiac bFGF and TGF beta-1 mRNA and their protein expression level were determined by immunohistochemistry and in situ hybridization as well as image analysis; cardiomyocytes and fibril collagen of type I and III were examined by haemotoxylin and eosin (HE) staining or sirius-red staining.

Results: Cardiocyte transverse diameter and fibril collagen of extracellular matrix, intracardiac bFGF and TGF beta-1 mRNA and their protein expression level in patients with volume or pressure-overload were significantly increased in both VG and PG, as compared with CG.

Conclusion: This is the first paper to suggest that intracardiac bFGF and TGF beta-1 play a pivotal role in patients with pressure or volume-overload leading to right or left ventricular hypertrophy, composed of cardiomyocyte hypertrophy and extracellular matrix proliferation.

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Source
http://dx.doi.org/10.2143/AC.60.1.2005044DOI Listing

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