A case of acute lymphoblastic leukaemia, associated with cells resembling Gaucher cells in the bone marrow, is reported. The patient had no evidence of inherited Gaucher's disease and the ultrastructural appearance of the cells was consistent with pseudo-Gaucher cells described in other haematological diseases. This is the first report of these cells in association with acute lymphoblastic leukaemia.
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http://dx.doi.org/10.1136/jcp.45.4.360 | DOI Listing |
Am J Hematol
January 2025
Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy.
Blood Res
February 2024
Department of Hematology, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110049, India.
Br J Haematol
October 2023
Department of Haematology, Royal North Shore Hospital, St Leonards, Australia.
Br J Haematol
September 2023
Department of Hematology, Mubarak Al Kabeer Hospital, Kuwait.
Niemann-Pick disease (NPD) A/B is a lysosomal storage disease (LSD), caused by an autosomal recessive disorder that causes variation in sphingomyelin phosphodiesterase-1 (SMPD1). Systemic signs are cholestatic jaundice in the neonatal period or hepatosplenomegaly in infancy. The clinical course experienced by our patient did not correspond to the classic phenotypes.
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