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Activation of Evolutionarily Young Endogenous Retroviruses Is Implicated in COVID-19 Immunopathology.
Genes Cells
January 2025
Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
The dysfunction of the innate immune system is well-described as a clinical characteristic of COVID-19. While several groups have reported human endogenous retroviruses (ERVs) as enhancing factors of immune reactivity, characterization of the COVID-19-specific ERVs has not yet been sufficiently conducted. Here, we revealed the transcriptome profile of more than 500 ERV subfamilies and innate immune response genes in eight different cohorts of platelet, peripheral blood mononuclear cells (PBMCs), lung, frontal cortex of brain, ventral midbrain, pooled human umbilical vein endothelial cells (pHUVECs), placenta, and cardiac microvascular endothelial cells (HCMEC) from COVID-19 patients (total; n = 124) and normal samples (total; n = 53) using publicly available datasets.
View Article and Find Full Text PDFPeripartum Cesarean Hysterectomy for Placenta Percreta: A Retrospective Analysis of Cases With and Without Extrauterine Disease.
Cureus
October 2024
Department of Obstetrics and Gynecology, Mansoura University, Mansoura, EGY.
Article Synopsis
- The study aimed to compare maternal morbidity and prenatal characteristics between two groups of women with placenta percreta: those with extrauterine disease (group B) and those with disease confined to the uterus (group A).
- A total of 73 cases were analyzed, revealing significantly higher blood loss, injury rates, and complications in group B compared to group A, highlighting the increased risks associated with extrauterine disease.
- The findings suggest that specialized care for placenta accreta spectrum (PAS) is essential, as cases with extrauterine disease are more complex and lead to higher maternal morbidity, indicating a need for differentiation in treatment approaches.
β3-adrenergic agonist counters oxidative stress and Na-K pump inhibitory S-glutathionylation of placental cells: implications for preeclampsia.
Am J Physiol Cell Physiol
January 2025
Cellular Membrane Biology Group, Kolling Medical Research Institute, University of Sydney, New South Wales, Australia.
Oxidative stress from placental ischemia/reperfusion and hypoxia/reoxygenation (H/R) in preeclampsia is accompanied by Na-K pump inhibition and S-glutathionylation of its β1 subunit (GSS-β1), a modification that inhibits the pump. β3-adrenergic receptor (β3-AR) agonists can reverse GSS-β1. We examined the effects of the agonist CL316,243 on GSS-β1 and sources of H/R-induced oxidative stress in immortalized first-trimester human trophoblast (HTR-8/SVneo) and freshly isolated placental explants from normal-term pregnancies.
View Article and Find Full Text PDFHarnessing the Therapeutic Potential of Mesenchymal Stem Cells in Cancer Treatment.
Adv Pharm Bull
October 2024
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- * Mesenchymal stem cells (MSCs), which can be sourced from tissues like bone marrow and adipose, have unique properties that make them promising for cancer treatment, including their ability to differentiate into various cell types and target tumors.
- * MSCs and their exosomes show potential in delivering therapeutic agents and inhibiting cancer progression by disrupting key signaling pathways, but challenges remain in effectively utilizing them in therapies.
Associations between term cesarean delivery in the first pregnancy and second-pregnancy preterm delivery.
Acta Obstet Gynecol Scand
January 2025
Department of Clinical Science, University of Bergen, Bergen, Norway.
Introduction: Cesarean delivery has been shown to increase the risk of preterm delivery in future pregnancies. The association could be a direct result of the procedure, or because the indications that led to the cesarean delivery also increase the risk of preterm delivery in later pregnancies.
Material And Methods: 298 901 mothers with first and second singleton deliveries from 1999 to 2020 were investigated using data from the Medical Birth Registry of Norway linked with Statistics Norway.
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