A 77-year-old woman presented with an ulcerated nodule on her right lower eyelid that was unresponsive to broad-spectrum antibiotics or incision and drainage. Coccidioidomycosis was suspected because of previous serologic testing and concurrent indurated cutaneous nodules. Although skin biopsies were not diagnostic, cultures from the eyelid were positive for Coccidioides immitis. The patient was initially treated with oral fluconazole, with resolution of the eyelid and skin lesions. She ultimately completed a 6-month course of oral azole therapy, and at 18-month follow-up she was symptom free. Few cases of granulomatous coccidioidomycosis of the eyelids have been reported. The clinical features of this infection are not specific, and the diagnosis is often difficult. Presentation can mimic bacterial infection or malignant neoplasm, leading to delayed or inappropriate treatment. We describe an unusual ulcerative lesion of the eyelid that led to a diagnosis of disseminated coccidioidomycosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.iop.0000155854.21746.49 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways.
J Vis Exp
December 2024
Department of Medicine, New Jersey Medical School, Rutgers - The State University of New Jersey;
Fungi infect humans when environmental spores are inhaled into the lungs. The lung is a heterogeneous organ. Conducting airways, including bronchi and bronchioles, branch until terminating in the alveolar airspace where gas exchange occurs.
View Article and Find Full Text PDFNonoperative management for disseminated spinal blastomycosis with extensive lytic destruction in a 35-year-old male: illustrative case.
J Neurosurg Case Lessons
December 2024
Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi.
Background: The authors describe the case of a 35-year-old male who presented with back pain and painful masses on his upper extremities. He had a known sacral lesion identified 1 year prior at an outside facility, suspected to be coccidioidomycosis on biopsy, but the workup was not completed because the patient left against medical advice and was lost to follow-up. Computed tomography (CT) and magnetic resonance imaging revealed lytic destructive lesions involving the calvaria, thoracolumbar spine, and sacrum, concerning for an active and disseminated infection.
View Article and Find Full Text PDFUpdates in Coccidioidomycosis.
Infect Dis Clin North Am
December 2024
Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, Sacramento, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA; UC-Davis Center for Valley Fever. Electronic address:
Coccidioidomycosis is the clinical disease caused by the dimorphic pathogenic fungi Coccidioides immitis and C posadasii. The number of clinically recognized coccidioidomycosis cases continues to increase yearly including in regions outside the traditional regions of endemicity. Following inhalation of Coccidioides spores, the course may range from asymptomatic exposure with resultant immunity, to a subacute pulmonary illness, to life-threatening disseminated infection.
View Article and Find Full Text PDFConfronting the Challenges of Prevention, Diagnosis, and Management of Donor-Derived Coccidioidomycosis.
Transpl Infect Dis
December 2024
Division of Infectious Diseases, Mayo Clinic, Phoenix, Arizona, USA.
Development of a novel patient-reported outcome measure for disseminated coccidioidomycosis (valley fever).
J Antimicrob Chemother
December 2024
Clinical Outcomes Assesments, Clinical Outcomes Solutions, Folkestone, Kent, UK.
Background: Coccidioidomycosis (Valley Fever) is a dimorphic fungal infection endemic to the southwest United States, Mexico, Central and South America, which can lead to chronic debilitating illness and death.
Objectives: This qualitative study was conducted to develop a bespoke patient-reported outcome measure for patients with chronic disseminated coccidioidomycosis to assess health-related quality of life (HRQoL) impacts.
Patients And Methods: Online, first-person narratives of patient experiences of disseminated coccidioidomycosis were used to create a patient-centred conceptual model of symptoms and impacts of the condition.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!