The role of sigma1 receptors in non-acute pain has not been explored. In this study we show that both phases of formalin-induced pain were reduced by approximately 55% in sigma1 receptor knockout mice in comparison to wild-type animals. These results suggest that the tonic pain induced by formalin is altered in mice lacking sigma1 receptors, and highlight the potential usefulness of further studies of the role of sigma1 receptors in models of non-acute pain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejphar.2005.01.036 | DOI Listing |
Publication Analysis
Top Keywords
sigma1 receptors
12
formalin-induced pain
8
pain reduced
8
sigma1 receptor
8
receptor knockout
8
knockout mice
8
role sigma1
8
non-acute pain
8
sigma1
5
reduced sigma1
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!