Objective: The treatment of La Peyronie's disease comprises medical treatment during the inflammatory acute phase and surgical treatment at the stage of stabilization of the lesions. This technical report describes the Leriche technique for the treatment of the stable phase of La Peyronie's disease.
Operative Technique: Patients are operated on an outpatient basis under local anaesthesia, after localization of the plaque by intraoperative ultrasound of the penis with erection induced by physiological saline. A percutaneous tear of the plaque is performed with an 18 gauge needle.
Materials And Methods: Ten patients with a mean age of 58 years (range: 32-82 years) were operated for La Peyronie's disease between January 2002 and January 2004. They all presented with painless penile curvature on erection, but severe discomfort or impossibility of sexual intercourse. The patients were reviewed at 1 and to 3 months. The results were assessed in terms of the degree of penile straightening and resumption of sexual activity.
Results: Three patients obtained complete cure. Two patients gained sufficient penile straightening to allow sexual intercourse and recovery was insufficient to allow sexual intercourse for 3 patients, but the result was improved after a second or even a third attempt. The last 2 patients were classified as treatment failures and were treated by penile prosthesis in one case and by the Nesbit technique in the other case. The results observed at 1 month persisted at 3 months.
Conclusion: The Leriche technique for the treatment of La Peyronie's disease is a simple, minimally invasive technique with satisfactory results. It does not compromise a subsequent procedure and does not present any short-term or long-term complications.
Download full-text PDF |
Source |
---|
Biochem Biophys Res Commun
January 2025
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. Electronic address:
Objective And Significance: Transforming growth factor-beta (TGF-β) plays a pivotal role in breast development by modulating tissue composition during the developmental phase. The TGFβ type II receptor (TGFβ RII) is implicated in breast cancer and represents a valuable therapeutic target. Due to the off-target side effects of many existing TGFβI/TGFβ RII inhibitors, a more targeted approach to drug discovery is necessary.
View Article and Find Full Text PDFInt J Med Inform
December 2024
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Background: Solid organ transplantation (SOT) is vital for end-stage organ failure but faces challenges like organ shortage and rejection. Artificial intelligence (AI) offers potential to improve outcomes through better matching, success prediction, and automation. However, the evolution of AI in SOT research remains underexplored.
View Article and Find Full Text PDFGen Hosp Psychiatry
December 2024
School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430061, China; Department of Geriatrics, Hubei Provincial Hospital of Traditional Chinese Medicine (Affiliated Hospital of Hubei University of Chinese Medicine), Wuhan 430060, China. Electronic address:
Background: Depression and anxiety are prevalent among older adults. However, most older adults have poor access to age-specific mental health services. While Information technology-based Cognitive Behavioral Therapy (ICBT) has shown promise as an accessible alternative to face-to-face interventions, its effectiveness specifically within the older adults warrants further investigation.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
January 2025
Department of Audiology, Ankara Medipol University Faculty of Health Sciences, Ankara, Turkey. Electronic address:
Objectives: This study aims to evaluate musical pitch and timbre perception in children who stutter and compare the results with typically developing children.
Methods: A total of 50 participants were included in the study, consisting of 25 children with stuttering (mean age = 10.06 years; range 6-17 years) and 25 typically developing children (mean age = 10.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!