Calcium crystal-associated arthropathy (pseudogout) in a dog.

J Am Vet Med Assoc

Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.

Published: April 1992

Calcium pyrophosphate dihydrate (Ca2P2O7.2H2O) crystal-associated arthropathy (pseudogout) was diagnosed in a dog. Clinical signs included non-weightbearing lameness, signs of pain on joint manipulation, and high rectal temperature. Arthrocentesis of carpal joints revealed extra- and intracellular crystals containing calcium. The suspected cause was polyarthritis secondary to chronic Ehrlichia infection. Results of joint tap performed after resolution of the clinical signs were negative for calcium pyrophosphate dihydrate crystals.

Download full-text PDF

Source

Publication Analysis

Top Keywords

crystal-associated arthropathy
8
arthropathy pseudogout
8
calcium pyrophosphate
8
pyrophosphate dihydrate
8
clinical signs
8
calcium
4
calcium crystal-associated
4
pseudogout dog
4
dog calcium
4
dihydrate ca2p2o72h2o
4

Similar Publications

Article Synopsis
  • Urate-lowering treatment (ULT) using xanthine oxidase inhibitors (XOIs) initially increases gout flare-ups, and researchers aimed to understand inflammation responsiveness by analyzing blood samples from two independent trial cohorts over 48 weeks.
  • The study found that after 48 weeks of ULT, serum urate levels normalized in patients and associated proteins indicated reduced inflammation and included key mediators of gout flare-ups, such as C5 and IL-1B.
  • Mechanistic studies revealed that febuxostat treatment reduced proteins linked to complement activation in cultured macrophages, suggesting that monitoring serum proteins may help identify the decline of gouty inflammation in response to ULT.
View Article and Find Full Text PDF

Neutrophils and extracellular traps in crystal-associated diseases.

Trends Mol Med

September 2024

Renal Division, Department of Medicine IV, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address:

Crystalline material can cause a multitude of acute and chronic inflammatory diseases, such as gouty arthritis, silicosis, kidney disease, and atherosclerosis. Crystals of various types are thought to cause similar inflammatory responses, including the release of proinflammatory mediators and formation of neutrophil extracellular traps (NETs), processes that further promote necroinflammation and tissue damage. It has become apparent that the intensity of inflammation and the related mechanisms of NET formation and neutrophil death in crystal-associated diseases can vary depending on the crystal type, amount, and site of deposition.

View Article and Find Full Text PDF

Describing calcium pyrophosphate deposition: undoing the tower of Babel!

Curr Opin Rheumatol

May 2024

IRCCS Ospedale Galeazzi - Sant'Ambrogio, Rheumatology Department, Milan, Italy.

Purpose Of Review: In 1977, McCarty astutely observed, 'The variety of names suggested for the condition associated with deposits of calcium pyrophosphate dihydrate crystals is exceeded only by the variations of its clinical presentation'. Fast forward to 2024, a standardized nomenclature for calcium pyrophosphate deposition (CPPD) is still lacking. This review aims to delineate the challenges in characterizing CPPD through nomenclature and imaging.

View Article and Find Full Text PDF

Introduction: This study aimed to compare the efficacy of non-loading versus loading low-dose colchicine in patients with acute crystal-associated arthritis.

Materials And Methods: All in-patients who were admitted to Chiang Mai University Hospital with non-arthritis disease and developed acute crystal-associated arthritis during admission (within 48 h after arthritis onset) were invited to join this study. The patients were randomized into two groups.

View Article and Find Full Text PDF

Objective: To characterize dual-energy computed tomography (DECT) changes depicting hyaline cartilage changes in gout patients with and without osteoarthritis (OA) and in comparators without gout.

Design: Patients with suspected crystal-associated arthropathy were enrolled and underwent bilateral DECT scans of the knees. Standardized regions of interest were defined in the femorotibial hyaline cartilage.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!