Recent advances in non-destructive techniques for imaging of cancellous bone have made possible true three-dimensional (3D) quantification of trabecular architecture. The architectural property can be measured from 3D reconstruction of cancellous bone specimens. Examples of such procedures are model-independent assessment of trabecular dimensions, 3D connectivity estimation, degree of anisotropy and structure type assessment. These new techniques would be utilized for the analysis of bone microstructure in various pathophysiological models.
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