Hormone Replacement Therapy (HRT) is recognized as a gold standard for postmenopausal osteoporosis. Currently, various regimens and types of preparation are available in clinical field. However, there are still some issues remaining, such as risks of cancers, poor-responders, and side effects. We should follow current studies and information, and have a knowledge of advantages and disadvantages of HRT. In practical use, HRT needs to be tailored to the individual patient's risk and benefit, and to be performed under informed consent.
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