Selective estrogen receptor modulator (SERM) is a kind of drug that has agonistic and antagonistic effects of estrogen in different tissues. MORE study has shown that raloxyfene reduces osteoporotic vertebral fractures and serum cholesterol levels in postmenopausal women, while it does not stimulate the endometrium and decreases the breast cancer occurrence. There are more to be investigated like developing newer SERMs, a combination therapy with estrogen or the elucidation of mechanisms of estrogen effects.
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