We investigated the efficacy of concurrent use of two of 1alphaOH vitamin D(3), vitamin K(2), and EHDP in increasing lumbar BMD and in preventing new fracture in patients with primary osteoporosis. D(3) + K(2) showed little effect and was considered to be poor combination. EHDP + D(3) or EHDP + K(2) was superior to single use of these agents in both end points.
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