Objective: To estimate the prevalence of chronic venous insufficiency (CVI) in the Saudi adult population and to identify the association of CVI with possible risk factors.
Methods: Sixteen Primary Health Care (PHC) centers have been randomly selected in various districts of 3 major cities of Kingdom of Saudi Arabia, including Jeddah, Makkah and Dammam during the year 2001. Every Saudi patient, of both sexes and aged >18 years, visiting the selected PHC centres for any reason, was eligible. The study was conducted during 6 consecutive days. Patients' history, demographics and risk factors were recorded and clinical examination was performed in order to diagnose CVI according to the latest clinical severity, etiology or cause, anatomy, pathophysiology (CEAP) classification.
Results: A total of 2566 participants were recruited. Out of these, 2350 were included. Fifty-three percent of the included patients were females and 66% were from the Western region. The overall prevalence of CVI (from class 0 to 4) was 45.6% (95% confidence interval [CI] 43.6 - 47.6). Considering CVI with visible signs only (class 1 to 6), the prevalence was 38.3% (95% CI 36.6 - 40.2). It was found higher in female (49.6%) and in the Western region (43.0%). Chronic venous insufficiency was significantly associated with age, family history of CVI, prolonged standing occupation and the use of hormonal therapy.
Conclusion: These data demonstrated a high prevalence of CVI in the Saudi population, which is higher than in Western countries, especially in the Western region. This is probably linked to the high frequency of risk factors in the Saudi population and to the current lifestyle.
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Clin Breast Cancer
December 2024
Navarra University Hospital, Pamplona, Navarra, Spain. Electronic address:
Approximately one-third of patients with breast cancer have comorbidities at the time of their diagnosis. Recommendations for managing metastatic breast cancer are usually based on the results of clinical trials, which often limit patients with comorbidities. However, comorbidities greatly influence the quality of life, patient survival rate and treatment choice, particularly in older patients.
View Article and Find Full Text PDFObjectives: This study aimed to develop a prediction model for the detection of early sepsis-associated acute kidney injury (SA-AKI), which is defined as AKI diagnosed within 48 hours of a sepsis diagnosis.
Design: A retrospective study design was employed. It is not linked to a clinical trial.
Ann Vasc Surg
January 2025
1(st) Department of Pathology, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic.
Objectives: Studies comparing alternative autologous vein grafts (AAVG) to single-segment great saphenous vein (ssGSV) grafts report mixed results. The status of AAVG as first choice when ssGSV is unavailable is not unequivocal, based on current evidence. Our study compares results between AAVG and ssGSV in lower extremity bypass surgery.
View Article and Find Full Text PDFInt J Gynecol Cancer
January 2025
Division of Gynecologic Oncology, Obstetrics & Gynecology Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Objective: This study aimed to compare perioperative outcomes and progression-free and overall survival in patients with chronic kidney disease (CKD) versus those without after hyperthermic intra-peritoneal chemotherapy (HIPEC) for ovarian cancer.
Methods: This is a retrospective, single-institution cohort study of patients with ovarian cancer treated with HIPEC at the Cleveland Clinic from January 2009 to December 2022. All patients received HIPEC with cisplatin and renal protection with mannitol and furosemide.
Transfusion
January 2025
Hematology-Oncology and Cell Therapy University Institute, Hôpital Maisonneuve-Rosemont Research Center, Montréal, Quebec, Canada.
Background: Cold agglutinin disease (CAD) or syndrome (CAS) can be particularly challenging when autologous stem cell transplant (ASCT) is needed. Standard peripheral blood stem cell (PBSC) collection and manipulation involve ex vivo blood manipulations at lower than body temperature, predisposing to agglutination during graft collection, handling, processing, and infusion.
Study Design And Methods: We describe the first case of ASCT for relapsing lymphoma in a patient with high-titer CAD requiring anti-complement therapy and chronic transfusion.
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