AI Article Synopsis
- The study explored how certain gene variations in metabolizing enzymes relate to the risk of lung cancer, particularly in smokers.
- A case-control analysis included 217 lung cancer patients and 200 healthy controls, focusing on the genotype distributions of specific genes using PCR-RFLP methods.
- The findings showed a significant link between a GSTM1-null genotype and lung cancer risk, particularly for smokers, while no significant associations were found for other genotypes examined.
Article Abstract
Objective: To investigate the relationship between the gene polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer as well as to study the synergistic effects between smoking and the genes.
Methods: A case-control study (case = 217, control = 200) was carried out to compare the frequent distribution of CYP1A1, 2E1, 2D6 and GSTM1 genotypes between the lung cancer group and the control group with a polymerase chain reaction-restriction fragment polymorphism (PCR-RFLP) method and to analyze the relationship between these genes and smoking.
Results: GSTM1-null genotype frequency was 58.5% in the lung cancer group and 47.5% in the control group with significant difference (P = 0.02). The frequent distribution of CYP1A1, 2E1, 2D6 genotypes was not significantly different in the two groups (P > 0.05). Synergistic effects were found between smoking and GSTM1 but not between smoking and CYP1A1, 2E1, 2D6.
Conclusion: Smoking and GSTM1-null genotype seemed to be the risk factors of lung cancer. Those who carrying GSTM1-null genotype and smoking cigarettes were prone to suffer from lung cancer to become the high-risk population of the disease.
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