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Mesenchymal Stem Cell-conditioned Medium Attenuated CoCl2-induced Injury of Renal Tubular Epithelial Cells by Inhibiting NCOA1, HIF-1α, and Sox9.
Curr Pharm Des
January 2025
Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Backgrounds: Renal interstitial fibrosis (RIF) constitutes the ultimate pathological alteration in nearly all chronic kidney diseases (CKD). Mesenchymal stem cell conditioned medium (MSC-CM) exhibits an alleviating impact on renal fibrosis; however, the underlying mechanism remains unclear. The objective of this study was to explore whether MSC-CM regulates the expression of α-smooth muscle actin (α-SMA), Transforming growth factor-β1 (TGF-β1), Hypoxia-inducible factor-1α (HIF-1α), Nuclear receptor coactivators (NCOA1), and SRY-related high mobility (Sox9).
View Article and Find Full Text PDFSequential Epidemiological Analyses of Real-World Data: A Tool for Prospective Drug Safety Surveillance from the Rofecoxib Example.
Drug Saf
January 2025
Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
Introduction: Large administrative healthcare databases can be used for near real-time sequential safety surveillance of drugs as an alternative approach to traditional reporting-based pharmacovigilance. The study aims to build and empirically test a prospective drug safety monitoring setup and perform a sequential safety monitoring of rofecoxib use and risk of cardiovascular outcomes.
Methods: We used Danish population-based health registers and performed sequential analysis of rofecoxib use and cardiovascular outcomes using case-time-control and cohort study designs from January 2000 to September 2004.
Quality of Life Study in Chronic Diseases: More Needed Than Ever.
Acta Med Indones
October 2024
School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia - St Carolus Hospital, Jakarta, Indonesia.
Numerous thyroid diseases can impact patients' lives, one of which is Graves' ophthalmopathy (GO). Graves' ophthalmopathy is a progressive thyroid-related disease that causes eye symptoms due to an autoimmune reaction targeting thyrotropin/thyroid stimulating hormone (TSH) receptors in the orbital space. This condition can be easily recognized by the patient, including exophthalmos, pain, swelling, double vision, and impaired vision.
View Article and Find Full Text PDFThe Influence of Iron Particles and Polyethylene Glycol on Selected Properties of Polylactide-Based Composites.
Polymers (Basel)
January 2025
Faculty of Mechanical Engineering, Bialystok University of Technology, Wiejska 45C, 15-351 Bialystok, Poland.
This article presents the characteristics of composites comprising polylactide combined with iron powder, from 1 to 10 wt.%, and nanoiron powders with a mass fraction from 0.1 to 1.
View Article and Find Full Text PDFExperimental Study on Flexural Behaviour of Prefabricated Steel-Concrete Composite I-Beams Under Negative Bending Moment: Comparative Study.
Materials (Basel)
January 2025
School of Civil Engineering, Nanjing Tech University, Nanjing 211816, China.
The issues of numerous steel beam components and the tendency for deck cracking under negative bending moment zones have long been challenges faced by traditional composite I-beams with flat steel webs. This study introduces an optimized approach by modifying the structural design and material selection, specifically substituting flat steel webs with corrugated steel webs and using ultra-high-performance concrete for the deck in the negative bending moment zone. Three sets of model tests were conducted to compare and investigate the influence of deck material and web forms on the bending and crack resistance of steel-concrete composite I-beams under a negative bending moment zone.
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