Following contents were reviewed in this article: More and more experimental studies related with chronic uratic nephropathy were carried out in recent years. In most of these studies, the animal models were established mainly from viewpoints of gene recombination, urinary uric acid inhibition and blood uric acid production promoting. TCM showed good effects in lowering blood uric acid, regulating levels of cytokines and postponing interstitial fibrosis. However, further studies on Chinese herbs and their extracts is necessary.
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Cureus
December 2024
Diabetes and Endocrinology, Prabhath Diabetes Care Centre, Udupi, IND.
This meta-analysis investigates the potential of allopurinol to prevent contrast-induced nephropathy (CIN), a common and serious complication of percutaneous coronary intervention (PCI). CIN is particularly prevalent among high-risk populations, including patients with chronic kidney disease (CKD) or acute coronary syndrome (ACS), where the administration of contrast agents can exacerbate renal injury. Allopurinol, a xanthine oxidase inhibitor, is known for its dual action in reducing oxidative stress and uric acid production, positioning it as a promising therapeutic candidate to mitigate CIN.
View Article and Find Full Text PDFACS Omega
January 2025
Department of Physics, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
Chemical polymerization/oligomerization opens numerous opportunities, from fundamental materials research to practical applications in catalysis, energy, sensing, and medicine. The electrochemical detection of vitamins B (folic acid) and C (ascorbic acid) requires new approaches because of low selectivity, electrode fouling, and interference from other chemicals. As an excellent material for long-term vitamin detection, oligo 3,5-diamino-1,2,4-triazole (oligo DAT) enhances the sensitivity, selectivity, and stability of sensors by creating a stable, conductive layer that facilitates electron transfer and reduces interference from common substances like glucose or uric acid.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
January 2025
Department of Endocrinology and Metabolism, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, People's Republic of China.
Background/objective: Considering the uncertain relationship between high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) with diabetic retinopathy (DR),this study investigates the link between Uric Acid to High-Density Lipoprotein Cholesterol (UHR) and DR in T2DM patients, evaluating its potential for DR diagnosis and early prediction.
Study Design And Data Collection: This retrospective study analyzed 1450 type 2 diabetes patients, divided into NDR and DR groups by retinal exams. We gathered demographic and clinical data, calculated UHR, and explored its correlation with DR development.
Med Sci Monit
January 2025
Department of Cardiology, Kocaeli City Hospital, Health Sciences University, Kocaeli, Turkey.
BACKGROUND Coronary artery ectasia (CAE) is frequently present with coronary artery disease (CAD). However, it is not clear why some patients with CAD progress to CAE while others do not. The pathogenesis of CAE is still poorly elucidated.
View Article and Find Full Text PDFBMC Cardiovasc Disord
January 2025
Department of Cardiology, Northern Jiangsu People's Hospital, Nantong West Road No. 98, Yangzhou, Jiangsu, 225001, China.
Objectives: The aim of this study was to explore the correlation between blood test indicators and Atrial Fibrillation (AF) in Individuals Aged 65 and Older in Yangzhou, Jiangsu.
Methods: From January 1, 2019, to August 31, 2023, an epidemiological cross-sectional survey was conducted among the elderly population undergoing health check-ups at Northern Jiangsu People's Hospital in Jiangsu Province. Patients diagnosed with AF after a 12-lead electrocardiogram were included in the case group, and non-AF individuals matched by age and gender in a 1:4 frequency ratio were included in the control group.
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