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Stem Cells Treatment for Subarachnoid Hemorrhage.
Neurologist
October 2024
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Background: Subarachnoid hemorrhage (SAH) refers to bleeding in the subarachnoid space, which is a serious neurologic emergency. However, the treatment effects of SAH are limited. In recent years, stem cell (SC) therapy has gradually become a very promising therapeutic method and advanced scientific research area for SAH.
View Article and Find Full Text PDFIntraventricular baclofen for intractable spasticity and secondary dystonia: a frame-based stereotactic approach and case series.
Acta Neurochir (Wien)
October 2024
Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Objective: Intraventricular baclofen has been reported as an alternative to intrathecal baclofen for managing refractory spasticity and dystonia in some circumstances. In this report, we described a frame-based stereotactic approach for precisely positioning of the infusion catheter into the third ventricle.
Material And Methods: High resolution contrast-enhanced anatomical MR sequences was acquired prior to surgery for pre-planning.
PP2A activation overcomes leptomeningeal dissemination in group 3 medulloblastoma.
J Biol Chem
November 2024
Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address:
Leptomeningeal dissemination (LMD) is the primary cause of treatment failure in children with group 3 medulloblastoma (MB). Building on our previous work on protein phosphatase 2A (PP2A) activation in MB, here we present preclinical and molecular data on the effects of two novel classes of PP2A activators on disease processes of LMD in group 3 MB. The PP2A activators used in this study are ATUX-6156 and ATUX-6954 (diarylmethylcycloamine sulfonylureas), and ATUX-1215 and ATUX-5800 (diarylmethyl-4-aminotetrahydropyran-sulfonamides).
View Article and Find Full Text PDFCardiac alterations induced by Heloderma horridum horridum venom in rats: An experimental study with ECG analysis using a linear regression algorithm.
Toxicon
October 2024
Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Colonia las Viboras, Colima, 28040, Mexico; Facultad de Ciencias Químicas, Universidad de Colima, Kilometro 9 Carretera Colima-Coquimatlan, Coquimatlan, Colima, 28400, Mexico. Electronic address:
Article Synopsis
- Envenomation by Heloderma horridum, a lizard species, can cause notable physiological changes, particularly in heart function, as demonstrated in tests on Wistar rats.
- The study utilized a specialized computational linear regression algorithm to enhance the analysis of ECG data, achieving a 97.5% efficiency in detecting key heartwave components.
- Despite significant electrocardiographic changes and arrhythmias observed, there were no major signs of physical or inflammatory damage to the heart tissue, indicating that the venom primarily affects heart conduction rather than causing direct myocardial damage.
CCN1 Is a Therapeutic Target for Reperfused Ischemic Brain Injury.
Transl Stroke Res
July 2024
Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan.
Article Synopsis
- Ischemic stroke can cause inflammation that harms the brain, and there are special pathways (meningeal lymphatics) that help clear out bad stuff and immune cells from the brain.
- Researchers found that disrupting these pathways helped reduce brain damage and improved memory in mice after a stroke.
- A specific protein called CCN1 was involved in this process, and blocking it showed promise for protecting the brain from inflammation after a stroke.
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