Hepatitis C is an under-diagnosed and prevalent bloodborne illness, resulting in chronic cirrhosis in up to 25% of those infected. While the overall prevalence in the United States is 1.7%, high-risk populations may have up to 80% prevalence. The mechanism of transmission is well understood, but effective preventive measures are hampered by economic, social, and political factors. Antiviral treatment is expensive, and efficacy ranges from 40% to 85%. The value of screening high-risk populations has been demonstrated, and should be expanded; however, there is insufficient evidence to recommend universal screening for adults.
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http://dx.doi.org/10.1016/j.amepre.2004.12.009 | DOI Listing |
PLoS One
January 2025
School of Life Course and Population Sciences, King's College London, London, United Kingdom.
Introduction: High-Flow Nasal Therapy (HFNT) is an innovative non-invasive form of respiratory support. Compared to standard oxygen therapy (SOT), there is an equipoise regarding the effect of HFNT on patient-centred outcomes among those at high risk of developing postoperative pulmonary complications after undergoing cardiac surgery. The NOTACS trial aims to determine the clinical and cost-effectiveness of HFNT compared to SOT within 90 days of surgery in the United Kingdom, Australia, and New Zealand.
View Article and Find Full Text PDFActa Parasitol
January 2025
Department of Biomedicine and Biotechnology, Faculty of Medicine, University of Alcala, Alcala de Henares, Spain.
Purpose: Malaria remains a major global health challenge, particularly in sub-Saharan Africa and low- and middle-income countries (LMICs), contributing substantially to mortality and morbidity rates. In resource-limited settings, access to specialized diagnostic tests is often restricted, making basic blood analysis a valuable diagnostic tool. This study investigated the correlation between malaria infection and full blood count values in a rural region of Ghana during the 2022 rainy season, aiming to highlight diagnostic insights available from routine blood analyses.
View Article and Find Full Text PDFmSystems
January 2025
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
Unlabelled: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in the oral-maxillofacial region with a poor prognosis. Oral microbiomes play a potential role in the pathogenesis of this disease. However, findings from individual studies have been inconsistent, and a comprehensive understanding of OSCC-associated microbiome dysbiosis remains elusive.
View Article and Find Full Text PDFBackground: Babesiosis poses significant risks of adverse outcomes in individuals with immunocompromising conditions (IC) and asplenia/hyposplenia (AH). This study compares clinical outcomes between these vulnerable groups and immunocompetent patients.
Methods: A multicenter retrospective cohort study included adult patients with laboratory-confirmed babesiosis from 2009 to 2023.
Can J Infect Dis Med Microbiol
January 2025
Meat Microbiology, ICAR-National Meat Research Institute, Hyderabad, Telangana, India.
is an airborne bacterial zoonotic pathogen that causes Q fever/coxiellosis in humans and animals. Although dogs are suspected of transmitting Q fever to humans in past outbreaks, the prevalence of in the Indian dog population and risk factors for infection remain unknown. In this study, 452 dogs from pet clinics in three Indian states were screened for coxiellosis using molecular (Trans-PCR, Com 1-PCR) and serological (IFAT) tests.
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