Aim of the study was to evaluate retrospectively recent and late results of coronary artery bypass grafting (CABG) in patients with ischaemic heart disease and severe left ventricular dysfunction. 146 patients (125 men, 21 women) aged 58.4 +/- 8.4 years, with angina (Canadian Cardiac Society--CCS class > or = 1), heart failure (New York Heart Association--NYHA class > or = 1), left ventricular ejection fraction (LVEF < or = 30%), multi-vessel coronary disease were included to the study. All patients underwent CABG. Peri-operative mortality was 6.1%, in-hospital mortality was 8.2%, 1-year survival was 86.5% and 4-year survival--80%. It was shown that CABG improves angina, dyspnoea and LVEF in patients with coronary heart disease and depressed left ventricle function (LVEF < or = 30%). Selected parameters like: unstable angina requiring intra-aortic balloon pump (IABP) preoperatively, recent heart infarction, cerebrovascular disease, severly depressed left ventricle function (LVEF < or = 20%), mitral regurgitation and Cleveland score > or = 10 pts significantly influence early surgical results (up to 30 days after surgery). It was shown that independent parameters predicting long-term survival and risk of major cardiac events were: negative dobutamine stress test, significant mitral valve incompetence and Cleveland score > or = 10 pts. Use of crystalloid cardioplegia increases early risk of CABG however none of methods of myocardial protection affects long-term surgical results. The outcomes of procedures using blood cardioplegia or intermittent cross clamp and ventricular fibrillation are comparable.
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Drugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
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Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
Southern right whales (Eubalaena australis) are mysticete cetaceans commonly observed in the coastal waters of Brazil, particularly in Santa Catarina State. There is limited understanding of the causes of calf mortality in this species, particularly concerning infectious diseases. We report a case of omphalophlebitis caused by Streptococcus equi subsp.
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Pediatric Advanced Heart Failure and Heart Transplant Program, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS, USA.
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Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Recent evidence suggests that ketone bodies have therapeutic potential in many cardiovascular diseases including heart failure (HF). Accordingly, this has led to multiple clinical trials that use ketone esters to treat HF patients, which we term ketone therapy. Ketone esters, specifically ketone monoesters, are synthetic compounds which, when consumed, are de-esterified into two β-hydroxybutyrate (βOHB) molecules and increase the circulating βOHB concentration.
View Article and Find Full Text PDFJ Anat
January 2025
Hannover Medical School, Institute of Functional and Applied Anatomy, Hannover, Germany.
Obesity, along with hypoxia, is known to be a risk factor for pulmonary hypertension (PH), which can lead to right ventricular hypertrophy and eventually heart failure. Both obesity and PH influence the autonomic nervous system (ANS), potentially aggravating changes in the right ventricle (RV). This study investigates the combined effects of obesity and hypoxia on the autonomic innervation of the RV in a mouse model.
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