The general activity of cytochrome P-450 and of its isoenzymes P-450IA2 and P-450IIIA4 was studied by the pharmacokinetic findings of antipyrin in virtually healthy different-age children. According to the results, the P-450 cytochrome system gradually matures as the child grows up and it has its own specific features, which must be considered in pharmacotherapy of children as well as while purposefully affecting the system in order to activate the detoxication processes.
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