This article has addressed certain of the key federal regulatory schemes governing ASCs with which owners and operators of ASCs should be familiar. In addition to the regulatory schemes addressed herein, we encourage owners and operators of ASCs to familiarize themselves with other critical requirements such as those relating to antitrust issues, taxation issues and state requirements regarding licensure, certification, ownership arrangements, and reimbursement.
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Precise engineering of gene expression by editing plasticity.
Genome Biol
March 2025
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, 430070, China.
Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledge is fundamental for advancing genetic engineering and improving crop traits.
Results: We here demonstrate that CREs can be accurately predicted and utilized to precisely regulate gene expression beyond the range of natural variation.
Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety.
Front Toxicol
February 2025
Safety, Environmental and Regulatory Science (SERS), Unilever, Colworth Science Park, Sharnbrook, Bedfordshire, United Kingdom.
Introduction: This work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung effects using human upper and lower respiratory tract models, namely MucilAir™-HF and EpiAlveolar™ systems, respectively.
Methods: A 12-day substance repeated exposure scheme was established to explore potential lung effects through analysis of bioactivity readouts from the tissue integrity and functionality, cytokine/chemokine secretion, and transcriptomics.
Results: Eleven benchmark chemicals were tested, including inhaled materials and drugs that may cause lung toxicity following systemic exposure, covering 14 human exposure scenarios classified as low- or high-risk based on historical safety decisions.
Effects of engineering injection and supplement mode of in-situ biogeochemical transformation enhancement EVO-FeSO on the remediation of tetrachloroethylene contaminated aquifer.
J Environ Sci (China)
August 2025
Key Lab of Groundwater Resources and Environment Ministry of Education, Jilin University, Changchun 130021, China; Jilin Provincial Key Laboratory of Water Resources and Water Environment, Jilin University, Changchun 130021, China; National and Local Joint Engineering Laboratory for Petrochemical Contaminated Site Control and Remediation Technology, Jilin University, Changchun 130021, China. Electronic address:
Traditional in situ biogeochemical transformation suffers from competition among crucial microorganisms and inadequate formation of reactive minerals, thus leading to the accumulation of toxic intermediates. In this study, three regulation schemes were proposed to solve these problems from the perspective of engineering mode. Results showed intermittent injection mode effectively reduced the accumulation of toxic intermediates but the reduction rate of tetrachloroethylene was decreased.
View Article and Find Full Text PDFIndia's medical devices policy: exploring determinants in business ecosystem for export excellence.
J Health Organ Manag
March 2025
Indian Institute of Foreign Trade, New Delhi, India.
Purpose: This paper attempts to elucidate the fundamental determinants-both enablers and impediments-that shape a resilient business ecosystem for the medical devices sector in India, with a particular emphasis on sustainable export endeavours under the ambit of the Medical Devices Policy 2023.
Design/methodology/approach: This study dives into India's medical device export firms, analysing factors influencing their performance. By reviewing relevant literature, it identifies regulatory, manufacturing, marketing, distribution and import-related factors.
Obesity and overweight in R/R DLBCL patients is associated with a better response to treatment of R2-GDP-GOTEL trial. Potential role of NK CD8 + cells and vitamin D.
Cancer Metab
March 2025
Clinical Biochemistry Service, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma worldwide and is characterized by its heterogeneity. Although first-line therapy improves survival outcomes for DLBCL patients, approximately one third will relapse, often with a poor prognosis. Among the factors influencing prognosis and response to treatment in cancer patients, including those with lymphoma, overweight and obesity have emerged as significant considerations.
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