Death begets failure in the heart.

J Clin Invest

Department of Medicine, Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Published: March 2005

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1052022PMC
http://dx.doi.org/10.1172/JCI24569DOI Listing

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