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Cytotoxicity of methamphetamine exposure on Sertoli cells: a pilot study with implications for male infertility.
Drug Chem Toxicol
March 2025
Department of Medical Bioscience, Faculty of Natural Science, University of the Western Cape, Bellville, South Africa.
Methamphetamine (Meth), a psychoactive drug, has been shown to reduce testicular weight and decrease sperm count, indicating its potential role in contributing to male infertility. We therefore assessed Meth's effects (0.1-100 μM) on TM4 Sertoli cell viability, toxicity, and proliferation (trypan blue exclusion assay), mitochondrial activity (MA) (XTT assay), while transepithelial electrical resistance (TEER) was used to examine monolayer permeability.
View Article and Find Full Text PDFAn App-Based Intervention With Behavioral Support to Promote Brisk Walking in People Diagnosed With Breast, Prostate, or Colorectal Cancer (APPROACH): Process Evaluation Study.
JMIR Cancer
February 2025
Department of Behavioural Science and Health, University College London, London, United Kingdom.
Background: The APPROACH pilot study explored the feasibility and acceptability of an app (NHS Active 10) with brief, habit-based, behavioral support calls and print materials intended to increase brisk walking in people diagnosed with cancer.
Objective: Following UK Medical Research Council guidelines, this study assessed the implementation of the intervention, examined the mechanisms of impact, and identified contextual factors influencing engagement.
Methods: Adults (aged ≥18 y) with breast, prostate, or colorectal cancer who reported not meeting the UK guidelines for moderate-to-vigorous physical activity (≥150 min/wk) were recruited from a single hospital site in Yorkshire, United Kingdom.
Premorbid predictors of death at initial presentation of coronary heart disease in the Women's Health Initiative study.
Am J Prev Cardiol
March 2025
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Background: Premorbid health traits that increase the risk of dying at the time of initial presentation of coronary heart disease (CHD) remain poorly characterized.
Methods: We followed 148,230 post-menopausal participants in the Women's Health Initiative for a median of 13.3 years.
Bridging disciplines: An evaluation of learning about Interprofessional roles and responsibilities through an interactive group activity.
Curr Pharm Teach Learn
January 2025
University of Mississippi School of Pharmacy, Oxford, MS, United States of America.
The World Health Organization (WHO) defines interprofessional education (IPE) as "when two or more professions learn about, from and with each other", and considers IPE a necessary component of a "collaborative practice-ready" workforce. In this article we describe an interprofessional educational activity that focused on increasing students' knowledge of healthcare professionals' roles and responsibilities. Faculty members representing six healthcare related disciplines collaborated to develop an interactive group activity.
View Article and Find Full Text PDFHeart rate variability is more sensitive to stress than heart rate in specialist police undergoing selection.
PLoS One
January 2025
Tactical Research Unit, Bond University, Robina, QLD, Australia.
Police tactical group (PTG) officers respond to the most demanding and high-risk police situations. As such, PTG personnel require exceptional physical fitness, and selection for employment often evaluates fitness both directly and indirectly. While heart rate (HR) is often used to measure physical effort, heart rate variability (HRV) may be a valuable tool for measuring stress holistically.
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