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Dexmedetomidine suppresses glucose-stimulated insulin secretion in pancreatic β-cells.
FEBS Open Bio
December 2024
Department of Cell Physiology, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan.
Article Synopsis
- Proper glycemic control is important in critical care settings, as it can impact patient outcomes and is influenced by factors such as insulin secretion and glucose metabolism.
- Various perioperative drugs, particularly dexmedetomidine (DEX), are shown to suppress glucose-stimulated insulin secretion, but the mechanisms remain unclear.
- Research using pancreatic cell lines and primary cells indicates that DEX reduces insulin secretion without significantly altering other cellular processes, suggesting that it affects insulin signaling pathways and exocytosis mechanisms.
Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential.
Molecules
November 2024
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Cannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as a promising therapeutic agent with a diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option in the clinic. Recent research has shed light on CBG's intriguing molecular mechanisms, highlighting its potential to modulate multiple physiological processes.
View Article and Find Full Text PDFDexmedetomidine Attenuates Neuroinflammation-Mediated Hippocampal Neurogenesis Impairment in Sepsis-Associated Encephalopathy Mice through Central α2A-Adrenoceptor.
ACS Chem Neurosci
November 2024
Department of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Article Synopsis
- * Dexmedetomidine has been shown to help mitigate the negative effects on neural stem cells (NSCs) caused by inflammatory factors from sepsis, improving NSC growth and survival in a dose-dependent manner, but its exact mechanism is still unclear.
- * In animal studies, dexmedetomidine countered the neuroinflammation and cognitive decline linked to SAE, with its protective effects potentially involving the inhibition of specific receptors related to astrocyte activity.
Sperm collection in the domestic cat: A comparison of two techniques.
Theriogenology
January 2025
Auburn University College of Veterinary Medicine, Scott Ritchey Research Center, 1265 Morgan Drive, Auburn, AL, 36849, USA. Electronic address:
Semen collection in cats in the clinic setting can be difficult. However, semen analysis is vital when evaluating breeding soundness of a male. Electroejaculation (EEJ) is currently the most reliable semen collection method but requires specialized equipment and training of the operator.
View Article and Find Full Text PDFThe alpha2-adrenoceptor agonist clonidine protects against hypoxic-ischemic brain damage in neonatal mice through the Nrf2/NF-κB signaling pathway.
Immunol Lett
December 2024
Second Department of Orthopedic Rehabilitation, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
Neonatal hypoxic-ischemic brain damage (HIBD) is a severe condition closely associated with neuroinflammation and oxidative stress. Clonidine, a selective α2-adrenergic receptor agonist, is known for its anti-inflammatory and antioxidant properties. Despite these recognized therapeutic benefits, the exact mechanisms by which clonidine exerts its effects in the context of HIBD are not fully understood.
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