Objective: The aim of the present study was to investigate the perceived anxiety, depression, sleeping habits, and participation in social activities in relation to psychotropic drug use among elderly in assisted-living facilities and to identify factors of importance for the use of these drugs.
Method: The study had a cross-sectional design and included 93 residents living in old-age homes or in nursing homes in a municipality in southern Sweden. Data regarding medication was obtained from medical records and included all psychoactive drugs. The perceived anxiety, depression and sleeping habits of the residents were assessed using a structured interview questionnaire.
Results: Many of the residents had sleeping problems and also reported problems concerning anxiety and depression. Of the study population, 65 (70%) used one or more psychoactive drug; 9 were prescribed neuroleptics (10%), 29 anxiolytics (31%), 43 hypnotics (43%) and 31 were prescribed anti-depressants (33%). The most commonly used psychotropic drugs as it related to the residents' problems were: benzodiazepines (oxazepam) against anxiety, benzodiazepine-related agents (zoldipem and zopiclon) against insomnia and serotonin reuptake inhibitors (SSRI; citalopram) against depression. The residents who had been treated with psychotropic drugs at home continued this treatment after moving to assisted-living facilities and approximately 30% of the residents were prescribed new psychotropic drugs. Of those that perceived anxiety, insomnia or felt depressed, between 58% and 69%, respectively, had spoken to neither a nurse nor a physician about these problems. Of those that had talked to a nurse/physician about these problems, a majority had been prescribed psychotropic drugs. Factors of importance for treatment with psychotropic drugs against anxiety, insomnia and depression were: prior treatment with these drugs at home and discussing their problems with a physician.
Conclusion: The communication between the residents and the nurses/physicians appears to be insufficient as the residents state that they have not discussed their problems with a nurse or a physician and that the prescription of psychotropic drugs does not seem to be in proportion to the residents' perceived problems.
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Sci Rep
January 2025
Centre for Psychedelic Research, Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
The Relaxed Beliefs Under pSychedelics (REBUS) model proposes that serotonergic psychedelics decrease the precision weighting of neurobiologically-encoded beliefs. We conducted a preliminary examination of two psychological assumptions of REBUS: (a) psychedelics foster acute relaxation and post-acute revision of confidence in mental-health-relevant beliefs; which (b) facilitate positive therapeutic outcomes and are associated with the entropy of EEG signals. Healthy individuals (N = 11) were administered 1 mg and 25 mg psilocybin 4-weeks apart.
View Article and Find Full Text PDFChem Pharm Bull (Tokyo)
January 2025
Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Optimization of the manufacturing process based on scientific evidence is essential for quality control of active pharmaceutical ingredients. Real-time monitoring can ensure the production of stable quality crystals in the crystallization process. Raman spectroscopy is an attractive tool for pharmaceutical quality evaluation and process analytical technology because of its ability to analyze samples non-destructively and rapidly.
View Article and Find Full Text PDFPsychiatr Clin North Am
March 2025
Pediatric Psychiatry OCD and Tic Disorders Program, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Suite 2000, Boston, MA 02114, USA. Electronic address:
Tourette syndrome (TS) is associated with dysregulated cortico-striatal-thalamo-cortical neural circuitry, of which the primary implicated neurotransmitters include dopamine, glutamate, and gamma-aminobutyric acid. Pharmacologic intervention for tics should be considered when tics are causing psychological, functional, or physical impairment, and behavioral treatment is either inaccessible or ineffective. Only 3 medications have Food and Drug Administration approval for TS, including 2 typical antipsychotics (pimozide and haloperidol) and 1 atypical antipsychotic (aripiprazole).
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Clinical Pharmacology, Aalborg University Hospital, Aalborg, Region Nordjylland, Denmark
A middle childhood boy with epilepsy exhibited persistent low concentrations of valproic acid, lamotrigine and topiramate for over 1 month, primarily due to pharmacokinetic interactions involving fosphenytoin, meropenem and phenobarbital. Awareness of these clinically significant interactions is crucial for ensuring effective seizure control. However, further research is needed to establish optimal evidence-based treatment strategies in complex paediatric cases.
View Article and Find Full Text PDFCochrane Database Syst Rev
January 2025
Department of Psychiatry and Department of Epidemiology and Biostatistics, Western University, St Thomas, Canada.
Background: Generalised anxiety disorder (GAD) is a mental health condition characterised by excessive anxiety and worry about everyday events. GAD is a common disorder and generally affects women twice as often as men. Treatments include various psychological and pharmacological therapies.
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