Aim: To evaluate time trends in alcohol consumption habits and alcohol-related mortality among Kaunas (Lithuania) population aged 35--64 years from 1983 to 2002.
Material And Methods: The WHO MONICA study was carried out in Kaunas from 1983 to 2002. Alcohol consumption habits were determined using the data of four surveys among random samples of population aged 35-64 years (overall 3292 men and 3548 women, the response rate 65.1%). The source of mortality data is official mortality statistics of all permanent residents of Kaunas aged 35-64 years in 1983-2002. Age-standardized rates were calculated by the direct method and using World population as a standard. The trends were analyzed using the method of linear regression on logarithms of the age-standardized annual rates.
Results: Over the 20 years, the prevalence of regular alcohol consumption significantly increased among both men and women. At the same time, there was an increase in the study population of a mean level of consumed alcohol and the proportion of drinkers consuming alcohol frequently. During 1983 to 2002 mortality rates from external causes and suicides were increasing significantly among men (by 2.1%/yr., p = 0.039 and by 3.4%/yr., p = 0.0002, respectively) and have not changed among women.
Conclusion: Negative trends in alcohol consumption habits and alcohol-related mortality among urban Lithuanian population aged 35-64 years during the past 20 years were determined.
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Cancer Nurs
January 2025
Authors' Affiliation: The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Background: Colorectal cancer is the most common cancer globally, and its prevalence is high in minority populations.
Objectives: To investigate the effectiveness of a young adult community health advisor (YACHA)-led intervention in enhancing the colorectal cancer (CRC) screening uptake rate among asymptomatic South Asians aged 50 to 75 years residing in Hong Kong and to investigate the acceptability of this intervention.
Methods: A randomized controlled trial design was adopted.
Rev Inst Med Trop Sao Paulo
January 2025
Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Clínica de Moléstias Infecciosas e Parasitárias, Laboratório de Investigação Médica em Imunologia (LIM-48), SSão Paulo, São Paulo, Brazil.
Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Public Health, Kathmandu University Dhulikhel Hospital, Dhulikhel, Nepal.
Background: Gallbladder cancer (GBC) is a rare, highly fatal disease with diagnosis in advanced stage and low survival rate. Nepal ranked 4th position with highest rates of GBC for 10 countries in 2020.
Objective: To find the association between socio-demographic, behavioral and environmental factors associated with the development of GBC.
PLoS One
January 2025
Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom.
Background: Evidence for Mobile Stroke Units (MSUs) demonstrates that onset to treatment times for intravenous thrombolysis can be reduced and access to mechanical thrombectomy might be improved. Despite growing use of MSUs internationally, to date there have been no studies in NHS England and NHS Wales exploring the acceptability of MSUs to clinicians, patient and public representatives and other key stakeholders, which are important when considering potential feasibility and implementation.
Methods: This study used a mixed methods design with a cross-sectional survey and qualitative workshops and interviews between October 2023 to May 2024.
PLoS One
January 2025
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
Background: Epidemiological research suggests that altered levels of cytokine are associated with pathophysiology and the development of major depressive disorder (MDD). Based on earlier study, IL-1β rs16944 and rs1143627 polymorphisms may increase the risk of depression. Here, we aimed to evaluate the correlation between these polymorphisms and MDD susceptibility among the population in Bangladesh.
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