AI Article Synopsis
- Adenovirus (Ad) vectors are seen as promising tools for gene therapy due to their high efficiency in delivering genes and ability to target a wide range of cells.
- However, they have issues like being quickly cleared from the body and causing immune reactions, leading to temporary gene expression and difficulties in reusing the same Ad vector type.
- Despite past incidents of toxicity, research has continued to improve Ad vectors, resulting in meaningful progress in their use for gene therapy.
Article Abstract
Adenovirus (Ad) vectors have been expected to play a great role in gene therapy because of their extremely high transduction efficiency and wide tropism. However, due to the intrinsic deficiency of their immunogenic toxicities, Ad vectors are rapidly cleared from the host, transgene expression is transient, and readministration of the same serotype Ad vectors is problematic. As a result, Ad vectors are continually undergoing refinement to realize their potential for gene therapy application. Even after 1999, when a patient fatally succumbed to the toxicity associated with Ad vector administration at a University of Pennsylvania (U.S.) experimental clinic, enthusiasm of gene therapists for Ad vectors has not waned. With great efforts from various research groups, significant advances have been achieved through comprehensive approaches to improving the kinetics of Ad vector-delivered genes and gene products.
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| http://dx.doi.org/10.1016/j.addr.2004.12.010 | DOI Listing |
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