AI Article Synopsis
- A new series of effective pyrazolo[1,5-a]pyridine compounds has been discovered that inhibit the replication of herpes simplex virus 1.
- Various synthetic methods were created to easily produce a range of these compounds from common precursors.
- The research found that non-polar amines at specific positions on the compound enhance antiviral activity, with the presence of an NH group at the 2' position being crucial for keeping activity comparable to acyclovir, a well-known antiviral drug.
Article Abstract
A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage intermediates. Detailed examination of the amine substituents at the C2' position of the pyrimidine and C7 position of the core pyrazolopyridine is described. The antiviral data suggests that non-polar amines are preferred for optimal activity. Additionally, the 2' position has been shown to require an NH group to retain activity levels similar to that of the gold standard acyclovir.
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| http://dx.doi.org/10.1016/j.bmc.2005.01.044 | DOI Listing |
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