Historical dynamics of parameters of age-related mortality of Finnish men and women for the period 1952 to 2000 is studied. The Gompertz equation is found to describe age-related mortality of men quite exactly during the historical interval 1952 to 1989. From 1990 to 2000 for men and during the entire interval for women the Gompertz-Makeham equation is more exact. The constant component of mortality is found to be increasing since 1990 for men and since 1980 for women. The presence of the Strehler-Mildvan correlation is shown. There are 3 evidently separated periods: 1) from 1952 to 1971, 2) from 1972 to 1980, 3) from 1981 to 2000. The correlation has the highest value in the 1st and 3rd periods. During the 2nd, transitional, period the correlation value is minimal. An opinion is expressed that it's not correct to treat the incline coefficient of correlation dependence as a specific lifespan since it takes on different values even for a single country, though the values are stable during certain historical periods.
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HRB Open Res
January 2025
School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Background: Delirium and cognitive impairment are common in hip fracture populations and are associated with significant adverse patient outcomes. National hip fracture registries facilitate improvements in patient outcomes and care quality, such as reduced mortality and the development of specialist multidisciplinary services. However, there is substantial variation in the data collected and reported in relation to delirium and cognition, which impedes international comparison and may reduce quality of care.
View Article and Find Full Text PDFRedox Biol
January 2025
Aging and Metabolism Research Group, Korea Food Research Institute, Wanju-gun, South Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon-si, South Korea. Electronic address:
Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR), a β-carboline alkaloid, as a potential therapeutic agent for mitigating muscle aging.
View Article and Find Full Text PDFJ Physiol
January 2025
Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Motor neurons (MNs) within the nucleus ambiguus innervate the skeletal muscles of the larynx, pharynx and oesophagus, which are essential for swallow. Disordered swallow (dysphagia) is a serious problem in elderly humans, increasing the risk of aspiration, a key contributor to mortality. Despite this importance, very little is known about the pathophysiology of ageing dysphagia and the relative importance of frank muscle weakness compared to timing/activation abnormalities.
View Article and Find Full Text PDFBackground: Clonal hematopoiesis of indeterminate potential (CHIP) is the age-related presence of expanded somatic clones secondary to leukemogenic driver mutations and is associated with cardiovascular (CV) disease and mortality. We sought to evaluate relationships between CHIP with cardiometabolic diseases and incident outcomes in high-risk individuals.
Methods: CHIP genotyping was performed in 8469 individuals referred for cardiac catheterization at Duke University (CATHGEN study) to identify variants present at a variant allele fraction (VAF) ≥2%.
Clin Genitourin Cancer
January 2025
Department of Internal Medicine, University of Florida, Gainesville, FL.
Background: Prostate cancer is a leading cause of cancer-related mortality among men in the United States. Over the past two decades, the observed decline in prostate cancer mortality can be attributed to advancements in screening, early detection, and treatment. However, persistent disparities related to race, geography, and age highlight the need for targeted interventions to improve outcomes.
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