During the period of 1946-1956 ideas on the structure of the nucleic acids, especially DNA, were profoundly influenced by physico-chemical studies and, in particular, by electrometric titration studies pioneered by J. Masson Gulland and D.O. Jordan. It was eventually conclusively inferred when such studies had been sufficiently refined that: in DNA, the only hydrogen bonding that occurred was between the 1:6 amino groups of adenine and cytosine, and the -NH-CO "enolic" groups of thymine and guanine; the polynucleotide chains of DNA were not branched (or interrupted); and the internally hydrogen-bonded double-helical structure was stable both in aqueous solution and in the fibrous state.
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Department of Anaesthesiology and Intensive Care, Bicetre hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Le Kremlin Bicetre, France.
Intravenous fluid is administered during high-risk surgery to optimize stroke volume (SV). To assess ongoing need for fluids, the hemodynamic response to a fluid bolus is evaluated using a fluid challenge technique. The Acumen Assisted Fluid Management (AFM) system is a decision support tool designed to ease the application of fluid challenges and thus improve fluid administration during high-risk surgery.
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Acta Physiol (Oxf)
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Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
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View Article and Find Full Text PDFGenerating allogeneic CAR-NKT cells for off-the-shelf cancer immunotherapy with genetically engineered HSP cells and feeder-free differentiation culture.
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Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
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View Article and Find Full Text PDFObjective: The neuropsychological adverse effects of antiseizure medications (ASMs) influence the tolerability, and in turn effectiveness of these medications, which can occur in a dose-dependent fashion. In this study, we examine the neuropsychological effects of perampanel (PER) at 4 mg daily as this dose has not been previously assessed with objective cognitive tests.
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Europace
January 2025
Department of Cardiovascular Sciences, UZ Leuven, Leuven, Belgium.
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