The orbitofrontal cortex has extensive tight connections with the medial temporal tobe and medial thalamic structures, which are responsible for memory processing and consolidation. What is more, this cortex is constantly activated in the memory encoding processes. This makes the orbitofrontal cortex a critical region for memory formation. This cortex is also connected with the motor and hetero- and uni- modal association sensory cortices, the limbic cortices, and subcortical structures responsible for functions related with these systems. All these facts convert the orbitofrontal cortex into a nodal region within the neural networks responsible of selecting, assembling and analyzing, based on our memory, present and pass experiences, so that we can organize and decide the most appropriate behaviour in a given situation.
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