The understanding of testicular descent has changed much in the 20 years since the authors' laboratory began studying the mechanism. The process is now known to occur in 2 steps with different anatomy and hormonal regulation but with many still unresolved controversies. Recent advances include the recognition of acquired cryptorchidism of critical early postnatal germ cell development and the recommendation for surgery at 6 months of age. The authors still await long-term outcome studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpedsurg.2004.10.033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hormonal Function of Undescended Testes Before Orchidopexy in Prepubertal Boys.
J Clin Med
December 2024
Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, 90-419 Lodz, Poland.
The hormonal aspect of undescended testes (UDTs) in prepubertal boys, i.e., after mini-puberty, is poorly understood.
View Article and Find Full Text PDFCYP19 and ESR2 polymorphisms as potential culprits in cryptorchidism.
J Pediatr Urol
December 2024
Muğla Sıtkı Koçman University, Faculty of Medicine, Department of Pediatric Surgery, Muğla, Turkey.
Article Synopsis
- Cryptorchidism can lead to infertility and testicular cancer, with estrogen signaling being essential for testicle descent and hormonal imbalances contributing to the condition.
- The study aimed to examine the association between specific genetic variations (polymorphisms) in the CYP19 and ESR2 genes and the risk of developing cryptorchidism in children.
- Results showed significant differences in the frequency of certain genotypes and alleles between cryptorchid patients and healthy controls, suggesting that specific variations could increase the risk of cryptorchidism while others may provide protection.
Gonadotropin therapy for mini-puberty induction in male infants with hypogonadotropic hypogonadism: a systematic review.
J Clin Endocrinol Metab
December 2024
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Context: Congenital hypogonadotropic hypogonadism (CHH) is defined as an isolated deficiency of gonadotropin hormones. Mini-puberty, a transient postnatal activation of the hypothalamic-pituitary-gonadal axis in healthy infants, provides a window of opportunity to diagnose and treat CHH. Currently, in male infants with CHH, testosterone is used to increase phallus size.
View Article and Find Full Text PDFA Unique Case of Bilateral Testicular Tumours: Nonseminomatous Germ Cell Tumour and Contralateral Spermatocytic Tumour 27 Years Apart.
Urol Int
November 2024
Department of Urology, Asklepios Klinik Altona, Hamburg, Germany.
Introduction: Bilateral testicular tumours occur in 3-5% of all cases with testicular neoplasms. In the majority of cases, histology of the two new growths is identical. The time interval between the two neoplastic events rarely exceeds 10 years.
View Article and Find Full Text PDFExploring Testicular Descent: Recent Findings and Future Prospects in Canine Cryptorchidism.
Sex Dev
November 2024
Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Background: Canine cryptorchidism, manifested by an abnormal testicular position, poses significant health risks and reproductive challenges in affected males. Despite a high prevalence, estimated at up to 10% in the canine population, a comprehensive understanding of its pathogenesis remains elusive. Studies in human cryptorchids and knockout mice have identified key factors involved in testicular descent, including INSL3, RXFP2, and AR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!