AI Article Synopsis
- The study aimed to assess the effectiveness of a two-step embryo transfer (ET) procedure for patients with only two embryos on day 2, comparing it to a traditional single transfer method.
- The two-step group had significantly higher pregnancy (33.3% vs. 18.9%) and implantation rates (17.2% vs. 9.4%) than the control group, although many in the two-step group could not proceed to the second step due to the lack of viable blastocysts.
- The findings suggest that utilizing both day-2 ET and blastocyst transfer could be a beneficial approach for patients with limited embryos.
Article Abstract
Objective: To evaluate the effectiveness, for patients who have only two embryos on day 2, of a two-step (consecutive) embryo transfer (ET) procedure in which a cleaved embryo is transferred on day 2 and a single blastocyst is transferred on day 5.
Design: Observational comparative study.
Setting: Private IVF clinic.
Patient(s): Ninety two-step ET cycles were performed in patients who had two embryos on day 2 (two-step group). Ninety day-2 ET cycles were performed in age- and infertility-matched patients who had two embryos on day 2 (control group).
Intervention(s): Cleaved-ET, extended culture of one embryo, and a second transfer of a blastocyst.
Main Outcome Measure(s): Implantation and pregnancy rates.
Result(s): The pregnancy and implantation rates in the two-step group (respectively 33.3% and 17.2%) were significantly higher than those in the control group (18.9% and 9.4%). Thirty-nine of the patients in the two-step group (43.3%) could not proceed to the second step of ET because no viable blastocyst could be obtained, but four of them conceived anyway.
Conclusion(s): Taking advantage of both day-2 ET and blastocyst transfer, two-step ET may be an effective option for ET in patients who have an insufficient number of embryos.
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| http://dx.doi.org/10.1016/j.fertnstert.2004.07.974 | DOI Listing |
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