Purpose: To determine the metabolic characterization of a large solitary demyelinating lesion.
Methods: Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
Results: The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
Conclusion: The report summarizes the metabolic characteristics of a demyelinating plaque.
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| http://dx.doi.org/10.1016/j.jocn.2004.02.024 | DOI Listing |
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