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Editorial Commentary: Return-to-Play and Return-to-Sport Metrics Require Standardization.
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Bloomington, Minnesota.
It is commonly accepted that a primary goal of orthopaedic surgeries is to restore function for our patients, and to achieve this goal, many research studies aim to define outcomes that set a benchmark for knowing whether this mark is achieved. Unfortunately, return-to-play (RTP) and return-to-sport (RTS) metrics are often used without any strict definition or standardization. They often rely on patient recall, which could be biased, and often fail to distinguish level of performance after return to activity.
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January 2025
School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia. Electronic address:
H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells.
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Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Anticancer therapies can induce cellular senescence or drug-tolerant persistence, two types of proliferative arrest that differ in their stability. While senescence is highly stable, persister cells efficiently resume proliferation upon therapy termination, resulting in tumor relapse. Here, we used an ATP-competitive mTOR inhibitor to induce and characterize persistence in human cancer cells of various origins.
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