Purpose: The purpose of this in vitro study was to evaluate the sealing effects on tubule by three different dentin desensitizers.
Methods: 48 freshly extracted human premolars were selected. Their buccal dentin was exposed and a standardized circular area was isolated. They were randomly divided into three experiment groups and one control group. Dentin desensitizers included Systemp desensitizer, Seal&protect desensitizer and Gluma desensitizer. Twelve teeth were prepared for each test group (36 teeth total), and the other twelve teeth were selected as a control group. After the removal of cement, the dentin surfaces were cleaned, treated. Then the teeth were vertically cleaved into two sections. The surface and section of these teeth were observed by means of a scanning electron microscope.
Results: All 3 desensitizers could seal the tubules on dentin surface. Systemp desensitizer's dentin permeability was better than Seal&protect, but Gluma had no dentin permeability.
Conclusion: 3 desensitizers had sealing effect on tubule, systemo desensitizer was the best one.
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Mol Cancer Ther
January 2025
Tango Therapeutics (United States), Boston, United States.
Synthetic lethality approaches in BRCA1/2-mutated cancers have focused on poly(ADP-ribose) polymerase (PARP) inhibitors, which are subject to high rates of innate or acquired resistance in patients. Here, we used CRISPR/Cas9-based screening to identify DNA Ligase I (LIG1) as a novel target for synthetic lethality in BRCA1-mutated cancers. Publicly available data supported LIG1 hyperdependence of BRCA1-mutant cells across a variety of breast and ovarian cancer cell lines.
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View Article and Find Full Text PDFJ Infect Dev Ctries
December 2024
Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Introduction: The objective of this study was to assess the effectiveness of ivermectin and colchicine as treatment options for coronavirus disease 2019 (COVID-19).
Methodology: A three-arm randomized controlled clinical trial was conducted in the Triage Clinic of the family medicine department at Ain Shams University Hospitals on participants who had been diagnosed with moderate COVID-19. Patients aged < 18 years or > 65 years, with any co-morbidities, pregnant or lactating females, and those with mild or severe COVID-19 confirmed cases were excluded.
Polymers (Basel)
January 2025
Department of Chemistry and Chemical Technology, Manash Kozybayev North Kazakhstan University, Petropavlovsk 150000, Kazakhstan.
The aim of the work was to study the effect of additive concentration on changes in the adhesive and cohesive strength of bitumen. To evaluate the effectiveness of modifiers in the composition of binary and triple bitumen systems in relation to mineral fillers of two grades, the method of determination of the adhesive efficiency and thermodynamic calculations of adhesion and cohesion work were used. The following compounds were used as additives: synthesized from the oil refining waste and (waste sealing liquid).
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Qinghai Provincial Key Laboratory of Nanomaterials and Technology, School of Chemistry and Materials Science, Qinghai Minzu University, Xining 810007, China.
Sodium tungstate (NaWO) was filled into the micropores and onto the surface of a magnesium alloy microarc oxidation (MAO) coating by means of vacuum impregnation. Subsequently, the coating was sealed through silane treatment to synergistically boost its corrosion resistance. The phase composition of the coating was inspected using XRD.
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