From a total synthesis of cepabactin and its 3:1 ferric complex to the isolation of a 1:1:1 mixed complex between iron (III), cepabactin and pyochelin.

Bioorg Med Chem Lett

Métaux et Microorganismes: Chimie, Biologie et Applications, Département des Récepteurs et Protéines Membranaires (CNRS UPR 9050), Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant, F-67400 Illkirch, France.

Published: March 2005

A novel and straightforward total synthesis of cepabactin and its iron (III) complex is described. The latter compound was compared and identified to that obtained from the cultures of Burkholderia cepacia. On treatment of the growth medium of two different strains of B. cepacia with ferric chloride, we have isolated and characterized an unexpected mixed complex of iron (III), cepabactin and pyochelin.

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http://dx.doi.org/10.1016/j.bmcl.2005.01.034DOI Listing

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