AI Article Synopsis
- The researchers describe a method to create ethers of specific pyrroline compounds using a process that includes the formation of a cyclic sulfamidate.
- The study involved synthesizing new versions of two known compounds, epibatidine and tebanicline.
- The new compounds were then tested for their ability to alleviate pain using a mouse formalin model.
Article Abstract
We disclose an efficient procedure for the preparation of ethers of 2-substituted 2-hydroxymethylpyrroline and of 2-aminomethyl-3-pyrrolines, involving, as a key step, formation and nucleophilic ring opening of a cyclic sulfamidate. Several new analogs of epibatidine (1) and tebanicline (ABT-594, 2) were prepared and tested for analgesic activity in the mouse formalin model.
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| http://dx.doi.org/10.1016/j.bmcl.2005.01.058 | DOI Listing |
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