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Beta-Blockers After PCI for Stable Coronary Artery Disease and Preserved Left Ventricular Ejection Fraction.
JACC Adv
January 2025
Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Background: Limited data exist on the long-term impact of beta-blocker therapy after percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) and preserved left ventricular ejection fraction (LVEF).
Objectives: The aim of the study was to evaluate the effects of early beta-blocker initiation vs no initiation following PCI in patients with stable CAD and preserved LVEF.
Methods: This retrospective cohort study employed target trial emulation and incident user design, utilizing the TriNetx database (2009-2024).
Pharmacogenetic and microRNA mechanisms of beta blocker use on bone.
J Bone Miner Res
December 2024
Division of Endocrinology and Kogod Center on Aging, Mayo Clinic, Rochester, MN.
Motivated by studies showing an association between beta blocker (BB) use and positive bone outcomes, a pilot randomized control trial (RCT) was performed at the Mayo Clinic which randomized postmenopausal women to placebo, propranolol (40 or 80 mg twice daily), atenolol (50 mg/day), or nebivolol (5 mg/day) to determine changes in bone turnover markers (BTMs) and in bone mineral density (BMD) over 20 weeks. Pharmacogenetic effects and microRNA-mediated mechanisms involving beta adrenergic receptor and related genes have previously been found. We sought to validate these effects and discover new candidates in an ancillary study to the pilot clinical trial.
View Article and Find Full Text PDFThe effects of methimazole combined with propranolol on heart rate, bone metabolism, and thyroid hormone levels in patients with hyperthyroidism: A systematic review and a meta-analysis of case-control studies.
Medicine (Baltimore)
November 2024
Department of Pharmacy, Yaan People's Hospital, Yaan, China.
Background: The combination of methimazole and propranolol is considered an effective treatment regimen for hyperthyroidism in clinical practice; however, detrimental effects on the heart rate, bone metabolism and thyroid hormone levels have been reported. Therefore, the present study aimed to systematically review the efficacy and safety differences in patients with hyperthyroidism and the effects of treatment on heart rate, bone metabolism, cortisol, and adrenocorticotropic hormone levels using case-control studies.
Methods: Clinical case-control trials of methimazole combined with propranolol for the treatment of hyperthyroidism were selected from Chinese and English databases, and data were collected from the establishment of the database until August 2024.
Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer.
Cancers (Basel)
August 2024
Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa.
View Article and Find Full Text PDFIn situ forming hydrogels based on modified gellan gum/chitosan for ocular drug delivery of timolol maleate.
Int J Biol Macromol
October 2024
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- In situ forming hydrogels made from oxidized gellan gum and chitosan show promise for enhancing drug delivery in the eyes by prolonging the drug's presence.
- The synthesized hydrogels exhibited beneficial properties like high swelling, self-healing, and mucoadhesion, confirmed through various tests including FT-IR and SEM studies.
- In vitro tests indicated that hydrogels with more oxidized gellan gum released drugs faster and were non-toxic to bone marrow stem cells, proving their potential for glaucoma treatment.
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