Forty-eight randomly selected age-related human biological functions were analyzed in order to establish whether or not their (linear) regressions were modified by age-related standard errors. Possible reasons for this are advanced. Statistically significant multiple regressions were obtained in 25%, and 21% of the functions yielded statistically significant changes in the correlations between data and age when partial correlation coefficients were calculated. The conclusion is that age-related data need to be subjected to the above tests in order to minimize confounding factors.
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http://dx.doi.org/10.1093/gerona/60.1.35 | DOI Listing |
Cancers (Basel)
December 2024
Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Clonal hematopoiesis (CH) is associated with an increased risk of developing myeloid neoplasms (MNs) such as myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML). In general, CH comprises clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). It is an age-related phenomenon characterized by the presence of somatic mutations in hematopoietic stem cells (HSCs) and hematopoietic stem and progenitor cells (HSPCs) that acquire a fitness advantage under selection pressure.
View Article and Find Full Text PDFJ Physiol Investig
December 2024
Department of Pharmacology, Medical Faculty, Cukurova University, Adana, Turkey.
The alterations in bladder function are associated with aging. Hydrogen sulfide (H2S) is a gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to regulate bladder smooth muscle tone. The effects of age and urothelium on the L-cysteine/H2S-induced relaxant responses were investigated in young (3-4 months) and aged (23-24 months) mice.
View Article and Find Full Text PDFAging (Albany NY)
December 2024
Department of Molecular, Cell and Developmental Biology, Life Sciences Division, University of California, Los Angeles, CA 90095, USA.
Background: DNA methylation (DNAm)-based marker of aging, referred to as 'epigenetic age' or 'DNAm age' is a highly accurate multi-tissue biomarker for aging, associated with age-related disease risk, including cancer. Breast cancer (BC), an age-associated disease, is associated with older DNAm age and epigenetic age acceleration (age accel) at tissue levels. But this raises a question on the predictability of DNAm age/age accel in BC development, emphasizing the importance of studying DNAm age in pre-diagnostic peripheral blood (PB) in BC etiology and prevention.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
January 2025
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece; Division of Basic Sciences, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece. Electronic address:
Aesthetic Plast Surg
October 2024
Aesthetic Medical Center, China Medical University Hospital, No. 2, Yude Rd., North Dist., 404327, Taichung, Taiwan.
Background: Collagen dermal fillers have shown efficacy in addressing age-related changes in facial appearance. However, their potential in rejuvenating the periorbital region remains unexplored. The aim of this study was to evaluate the effectiveness, clinical safety, and patient satisfaction associated with the utilization of collagen dermal fillers in individuals with dermatochalasis and periorbital hyperpigmentation.
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