A note on age-related biomarkers.

J Gerontol A Biol Sci Med Sci

Institute of Gerontology, King's College London (University of London), Waterloo Bridge Wing, Waterloo Rd., London SE1 9NN, UK.

Published: January 2005

Forty-eight randomly selected age-related human biological functions were analyzed in order to establish whether or not their (linear) regressions were modified by age-related standard errors. Possible reasons for this are advanced. Statistically significant multiple regressions were obtained in 25%, and 21% of the functions yielded statistically significant changes in the correlations between data and age when partial correlation coefficients were calculated. The conclusion is that age-related data need to be subjected to the above tests in order to minimize confounding factors.

Download full-text PDF

Source
http://dx.doi.org/10.1093/gerona/60.1.35DOI Listing

Publication Analysis

Top Keywords

note age-related
4
age-related biomarkers
4
biomarkers forty-eight
4
forty-eight randomly
4
randomly selected
4
selected age-related
4
age-related human
4
human biological
4
biological functions
4
functions analyzed
4

Similar Publications

Implications of Clonal Hematopoiesis in Hematological and Non-Hematological Disorders.

Cancers (Basel)

December 2024

Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Clonal hematopoiesis (CH) is associated with an increased risk of developing myeloid neoplasms (MNs) such as myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML). In general, CH comprises clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). It is an age-related phenomenon characterized by the presence of somatic mutations in hematopoietic stem cells (HSCs) and hematopoietic stem and progenitor cells (HSPCs) that acquire a fitness advantage under selection pressure.

View Article and Find Full Text PDF

The alterations in bladder function are associated with aging. Hydrogen sulfide (H2S) is a gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to regulate bladder smooth muscle tone. The effects of age and urothelium on the L-cysteine/H2S-induced relaxant responses were investigated in young (3-4 months) and aged (23-24 months) mice.

View Article and Find Full Text PDF

DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility.

Aging (Albany NY)

December 2024

Department of Molecular, Cell and Developmental Biology, Life Sciences Division, University of California, Los Angeles, CA 90095, USA.

Background: DNA methylation (DNAm)-based marker of aging, referred to as 'epigenetic age' or 'DNAm age' is a highly accurate multi-tissue biomarker for aging, associated with age-related disease risk, including cancer. Breast cancer (BC), an age-associated disease, is associated with older DNAm age and epigenetic age acceleration (age accel) at tissue levels. But this raises a question on the predictability of DNAm age/age accel in BC development, emphasizing the importance of studying DNAm age in pre-diagnostic peripheral blood (PB) in BC etiology and prevention.

View Article and Find Full Text PDF

Mitostasis in age-associated neurodegeneration.

Biochim Biophys Acta Mol Basis Dis

January 2025

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece; Division of Basic Sciences, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece. Electronic address:

Article Synopsis
  • * Disruption in mitochondrial maintenance (mitostasis) leads to impaired neuronal function and is linked to age-related neurodegenerative diseases.
  • * Understanding mitochondrial homeostasis is essential for developing early diagnosis and treatment strategies for neurodegeneration.
View Article and Find Full Text PDF

Background: Collagen dermal fillers have shown efficacy in addressing age-related changes in facial appearance. However, their potential in rejuvenating the periorbital region remains unexplored. The aim of this study was to evaluate the effectiveness, clinical safety, and patient satisfaction associated with the utilization of collagen dermal fillers in individuals with dermatochalasis and periorbital hyperpigmentation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!