[Relationship between the expression of insulin-like growth factor I receptors and apoptosis after preliminary chemotherapy, in child and adolescent osteosarcoma].

Introduction: The influence of growth factors and apoptosis on the clinical course of neoplasms is of significant interest for oncologists, especially neoplasms with dynamic changes in proliferation, such as child and adolescent osteosarcoma.

Aim: To investigate reciprocal relations between the expression of insulin-like growth factor I receptors (IGF-IR) and index apoptosis ("pre-G l /G 0" fraction, DNA histograms) in osteosarcomas before operation and after preliminary chemotherapy.

Material And Methods: Flow cytometric analysis was carried out in 20 children and adolescents with osteosarcoma (aged 6 to 18 years) after preliminary chemotherapy. The material for investigation was taken during surgery.

Results: It was shown that higher expression of IGF-IR is associated with lower apoptosis index (% of apoptotic cells) and reversely (significant difference p
Conclusions: Investigations of the above relations are significant for better understanding of the influence of IGF-IR on the disease course and on the preliminary evaluation of cytostatic activity by way of apoptosis initiation.