Plain sinus radiography is the imaging technique most frequently used to investigate suspected rhinosinusitis, but it has low diagnostic sensitivity. Contiguous paranasal computerized tomography (CT) gives detailed information about the pathology, anatomy and anatomical variations of the paranasal sinuses, but this method also has limitations. The cost of using this technique for all cases of suspected rhinosinusitis is prohibitive, and complete CT scans involve considerable radiation exposure. The aim of this study was to devise a CT protocol for diagnosing and following rhinosinusitis that is more economical and involves much less radiation exposure than contiguous CT. In this retrospective study, three physicians independently reviewed the contiguous coronal paranasal CT studies of 136 patients. The study population comprised the adult patients who were investigated for suspected chronic rhinosinusitis. All scans had been obtained at the second visit, after the patient had completed a 3-week course of medical treatment. For each case, the same three slices were selected to form the "three-slice CT" exam, and the same physicians independently evaluated this set. Using the results from the contiguous set as the gold standard, we calculated the sensitivity and specificity of three-slice CT for identifying rhinosinusitis. The sensitivity and specificity of three-slice CT for identifying inflammatory sinus disease were 95.1 and 92.6%, respectively. Three-slice CT is a valuable method for diagnosing and following rhinosinusitis cases, and would be cheaper and involve less radiation exposure than contiguous coronal CT. However, despite the high cost and greater radiation exposure, contiguous CT remains the gold standard for evaluating detailed sinus anatomy and disease progression.
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http://dx.doi.org/10.1007/s00405-004-0896-8 | DOI Listing |
Acad Radiol
January 2025
Department of Radiology, University Hospital Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany (R.D., J.M.B., B.S., J.M., S.G., P.K., S.W., J.H., K.N., S.A., A.B.).
Rationale And Objectives: Photon Counting CT (PCCT) offers advanced imaging capabilities with potential for substantial radiation dose reduction; however, achieving this without compromising image quality remains a challenge due to increased noise at lower doses. This study aims to evaluate the effectiveness of a deep learning (DL)-based denoising algorithm in maintaining diagnostic image quality in whole-body PCCT imaging at reduced radiation levels, using real intraindividual cadaveric scans.
Materials And Methods: Twenty-four cadaveric human bodies underwent whole-body CT scans on a PCCT scanner (NAEOTOM Alpha, Siemens Healthineers) at four different dose levels (100%, 50%, 25%, and 10% mAs).
Mutat Res Rev Mutat Res
January 2025
Radiation Epidemiology Branch, National Cancer Institute, MD 20892-9778, USA; Faculty of Health, Science and Technology, Oxford Brookes University, Headington Campus, OX3 0BP, UK.
Biological effects of ionizing radiation vary with radiation quality, which is often expressed as the amount of energy deposited per unit length, i.e., linear energy transfer (LET).
View Article and Find Full Text PDFHealth Phys
January 2025
Nuclear Medicine and Molecular Imaging Sciences Program, Department of Clinical & Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL.
Ionizing radiation on the skin has the potential to cause various sequelae affecting quality of life and even leading to death due to multi-system failure. The development of radiation dermatitis is attributed to oxidative damage to the skin's basal layer and alterations in immune response, leading to inflammation. Past studies have shown that [18F]F-2-fluoro-2-deoxyglucose positron emission tomography-computed tomography ([18F]F-FDG PET/CT) can be used effectively for the detection of inflammatory activity, especially in conditions like hidradenitis suppurativa, psoriasis, and early atherosclerosis.
View Article and Find Full Text PDFSmall
January 2025
College of Chemistry, Fuzhou University, Fuzhou, 350116, P. R. China.
Metal-free molecular perovskites have shown great potential for X-ray detection due to their tunable chemical structures, low toxicity, and excellent photophysical properties. However, their limited X-ray absorption and environmental instability restrict their practical application. In this study, cesium-based molecular perovskites (MDABCO-CsX, X = Cl, Br, I) are developed by introducing Cs at the B-site to enhance X-ray absorption while retaining low toxicity.
View Article and Find Full Text PDFWomens Health (Lond)
January 2025
Department of Pharmacy Practice, Midwestern University College of Pharmacy, Glendale Campus, Glendale, AZ, USA.
In 2023, a breast cancer risk assessment and a subsequent positive test for the BRCA-2 genetic mutation brought me to the uncomfortable intersection of a longstanding career as an advocate for high-quality medical evidence to support shared patient-provider decision making and a new role as a high-risk patient. My search for studies of available risk-management options revealed that the most commonly recommended approach for women with a ⩾20% lifetime breast cancer risk, intensive screening including annual mammography and/or magnetic resonance imaging beginning at age 25-40 years, was supported only by cancer-detection statistics, with almost no evidence on patient-centered outcomes-mortality, physical and psychological morbidity, or quality of life-compared with standard screening or a surgical alternative, bilateral risk-reducing mastectomy. In this commentary, I explore parallels between the use of the intensive screening protocol and another longstanding women's health recommendation based on limited evidence, the use of hormone therapy (HT) for postmenopausal chronic disease prevention, which was sharply curtailed after the publication of the groundbreaking Women's Health Initiative trial in 2002.
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